Results 321 to 330 of about 14,896,814 (380)

Selective Inhibition of the ABCG2 Transporter by Primaquine Derivatives Reverses the Multidrug Resistance of Tumor Cells. [PDF]

Int J Mol Sci
Mioč M, Beus M, Carević K, Rajić Z, Sarkadi B, Telbisz Á, Kralj M.   +6 more
europepmc   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Circulating Tumor Cells in Early Breast Cancer: A 10-Year Follow-Up Update. [PDF]

Biomedicines
Rossi T, Scarpi E, Maltoni R.
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Advanced Detection of Pancreatic Cancer Circulating Tumor Cells Using Biomarkers and Magnetic Particle Spectroscopy. [PDF]

Nanotheranostics
Dinari A, Ahmad HA, Oh S, Kim YH, Yoon J.   +4 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Comparative transcriptomic and genomic analysis of tumor cells in the marginal and center regions of tumor nests in human hepatocellular carcinoma. [PDF]

Front Cell Dev Biol
Li Z, Hu Y, He Z, Xu H, Wang H, He Y.
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

RNAi Screening in Tumor Cells Identifies Artificial microRNAs That Improve Oncolytic Virus Replication. [PDF]

Pharmaceuticals (Basel)
Klemets H, Bardoul A, Pelin A, Singaravelu R, Boileau M, Falls T, Petryk J, Bourgeois-Daigneault MC, Bell JC, Roy DG.   +9 more
europepmc   +1 more source

Enumeration, classification and clinical application of circulating tumor cells in advanced gallbladder adenocarcinoma. [PDF]

BMC Cancer
Liu C, Yan C, Zhang W, Sun Y, Lin Y, Cai W.   +5 more
europepmc   +1 more source