Results 321 to 330 of about 15,400,316 (399)

Circulating tumor cells as predictive biomarkers in the risk stratification of DCIS: Evidence of early dissemination. [PDF]

Sci Adv
Nagpal N, Rupp B, Hong Y, Wagner J, Larson K, Balanoff C, Aripoli A, Huppe A, Winblad O, Peterson J, Hill M, Smith C, Fabian C, Godwin AK, Fields T, Wicha M, Behbod F, Nagrath S.   +17 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Detection of biogenic magnetic nanoparticles in rapidly dividing tumor cells by the nonlinear magnetization method. [PDF]

Front Bioeng Biotechnol
Milovanova MV, Gabashvili AN, Mochalova EN, Gurtovaya EO, Egorova IE, Dresviannikova AA, Griaznova OY, Nikitin PI.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Size Matters: Small Circulating Tumor Cells Indicate Worse Therapy Response in Breast Cancer. [PDF]

MedComm (2020)
Wenta R, Muchlińska A, Suchodolska G, Senkus E, Żaczek A, Bednarz-Knoll N.   +5 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas. [PDF]

NPJ Precis Oncol
Bullova P, Cui P, Arceo M, Zhu J, Li W, Plescher M, Poltorachenko V, Stripling K, Santangeli C, Mykhaylechko L, Kastriti ME, Larsson C, Juhlin CC, Mints M, Schlisio S.   +14 more
europepmc   +1 more source

Targeting B7-H3 in solid tumors: Development and evaluation of novel CAR-T Cell therapy

Ning Li, Chunhua Zhang, Xiaoyu Li, Shufen Liu, Youhua Xu, Xifei Yang   +5 more
openalex   +1 more source