Results 31 to 40 of about 3,166,261 (352)
Biomedicines, 2023 The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the
Areti Strati +3 more
doaj +1 more source
Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]
, 2011 Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny +6 more
core +1 more source
Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]
, 2018 Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico +11 more
core +1 more source
Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro [PDF]
, 2016 A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay.
Li, Depeng +4 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 Non-canonical secretion pathways, collectively known as unconventional protein secretion (UPS), are alternative secretory mechanisms usually associated with stress-inducing conditions.
Rebeca Piatniczka Iglesia +18 more
doaj +1 more source
Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. [PDF]
, 2019 Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies.
Ames, Erik +8 more
core +1 more source
Advanced Science, 2022 Compromised immunosurveillance leads to chemotherapy resistance and disease relapse of hematological malignancies. Amino acid metabolism regulates immune responses and cancer; however, a druggable amino acid metabolite to enhance antitumor ...
Changzheng Li +15 more
doaj +1 more source
Multiplex detection of ten ESR1 mutations and AKT1 E17K in breast cancer using digital PCR
The Journal of Liquid BiopsyIntroduction: ESR1 mutations are now established as a key mechanism of resistance to endocrine therapy in estrogen-receptor–positive breast cancer (ER+ breast cancer) and their sensitive and specific detection in plasma-cell free DNA (plasma-cfDNA) is ...
Stavroula Smilkou +4 more
doaj +1 more source
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]
, 2016 A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon +15 more
core +2 more sources
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
, 2017 The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert +3 more
core +2 more sources