Results 31 to 40 of about 2,987,261 (338)

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. [PDF]

, 2017
Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments. Whether tumors exploit unique biophysical properties to metastasize remains unclear.
Barnes, J Matthew, Bell, Emily S, Cassereau, Luke, Chang, Alice C, Davidson, Michael W, DuFort, Christopher C, Dunn, Alexander R, Kai, FuiBoon, Lakins, Jonathan N, Lammerding, Jan, McGregor, Alexandra L, Mekhdjian, Armen H, Odde, David J, Ou, Guanqing, Pickup, Michael W, Prahl, Louis S, Przybyla, Laralynne M, Rubashkin, Matthew G, Tan, Steven J, Weaver, Valerie M, Ye, Xin   +20 more
core   +1 more source

The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]

, 2019
Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel, Ermatov, Nurmukambed, Konger, Raymond L., Ren, Lu, Sahu, Ravi P.   +4 more
core   +1 more source

Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression

Frontiers in Cell and Developmental Biology, 2022
Non-canonical secretion pathways, collectively known as unconventional protein secretion (UPS), are alternative secretory mechanisms usually associated with stress-inducing conditions.
Rebeca Piatniczka Iglesia, Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Rodrigo Nunes Alves, Maria Isabel Melo Escobar, Camila Felix de Lima Fernandes, Ailine Cibele dos Santos Fortes, Maria Clara da Silva Souza, Jacqueline Marcia Boccacino, Giovanni Cangiano, Samuel Ribeiro Soares, João Pedro Alves de Araújo, Deanna Marie Tiek, Anshika Goenka, Xiao Song, Jack Ryan Keady, Bo Hu, Shi Yuan Cheng, Marilene Hohmuth Lopes   +18 more
doaj   +1 more source

Method of Detecting and Targeting Mutations in Cancer [PDF]

, 2007
While there are many differences between tumor and non-tumor cells, the basic underlying distinction is in the DNA. Tumor cells harbor mutations, at least some of which are not present in non-tumor cells.
Byard Edwards
core   +2 more sources

Effect of immunization with fetal cells on adenovirus-12 oncogenesis [PDF]

, 1974
The effect of immunization with hamster fetal cells on the tumor induction by adnovirus type 12 was studied by in vivo and in vitro. The immunization with lO-day old fetal cells showed a recognizable inhibition on the tumor induction by adenovirus type ...
Abe, Shinji
core   +1 more source

Somatic gene therapy for cancer. The utility of transferrinfection in generating ‘tumor vaccines’ [PDF]

, 1993
The last few years have seen the development of a branch of somatic gene therapy which aims at strengthening the immune surveillance of the body, leading to eradication of disseminated cancer tumor cells and occult micrometastases after surgical removal ...
Aoki, Asher, Blankenstein, Bohle, Bubenik, Chen, Cloudman, Colombo, Cotten, Curiel, Dorsch, Dranoff, Ernst Wagner, Esumi, Fearon, Fearon, Gansbacher, Gansbacher, Georg Stingl, Golumbek, Groen, Hock, Hock, Itaya, Ito, Janeway, Kenne, Kurt Zatloukal, Kushtai, Lake, Lake, Lehner, Ley, Liebrich, Lindenmann, Linsley, Lurquin, Maraguchi, Matthew Cotten, Max L. Birnstiel, Nossal, Ohe, Ostrand-Rosenberg, Pardoll, Plaksin, Porgador, Restifo, Rollins, Roth, Russell, Schwartz, Tepper, Tepper, Townsend, Van der Bruggen, Van Pel, Wagner, Wallack, Walter Schmidt, Watanabe, Zatloukal   +60 more
core   +1 more source

Enhancement of experimental metastasis by tumor necrosis factor [PDF]

, 1993
The influence of endogenous and exogenous tumor necrosis factor (TNF) on metastasis was investigated in an experimental fibrosarcoma metastasis model.
Echtenacher, Bernd, Falk, Werner, Männel, Daniela N., Orosz, P., Rüschoff, J., Weber, D.   +5 more
core   +2 more sources

A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, 2022
Compromised immunosurveillance leads to chemotherapy resistance and disease relapse of hematological malignancies. Amino acid metabolism regulates immune responses and cancer; however, a druggable amino acid metabolite to enhance antitumor ...
Changzheng Li, Xinru You, Xi Xu, Binghuo Wu, Yuye Liu, Tong Tong, Jie Chen, Yishan Li, Chunlei Dai, Zhitao Ye, Xiaobin Tian, Yan Wei, Zechen Hao, Linjia Jiang, Jun Wu, Meng Zhao   +15 more
doaj   +1 more source

Effect of astragaloside Ⅳ on SK ⁃ N ⁃ SH cells damage induced by 1 ⁃ methyl ⁃ 4 ⁃ phenylpyridine in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the effect of astragaloside Ⅳ on the injury of SK⁃N⁃SH cell in Parkinson's disease (PD) induced by 1 ⁃ methy ⁃ 4 ⁃ phenylpyridine (MPP＋) and its mechanism.
HUANG Xiao⁃jing, HUANG Huai, XU Zheng⁃hu, HUANG Wan⁃gang, YANG Dong⁃feng, REN He⁃cheng   +5 more
doaj   +1 more source

Interactions of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) with the Immune System: Implications for Inflammation and Cancer [PDF]

, 2019
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL has historically been distinct from the Fas ligand and TNFα in terms of selective apoptosis induction in tumor cells and has a nearly non ...
Baukloh, Ann-Kathrin, Beyer, Katharina, Kamphues, Carsten, Kotsch, Katja, Sattler, Arne, Stoyanova, Ani   +5 more
core   +1 more source