Results 171 to 180 of about 37,102 (217)

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

LAMC2 Drives Airway Remodeling in COPD via EMT Regulation Through the AKT Pathway. [PDF]

Int J Chron Obstruct Pulmon Dis
Wang Z, Shi J, Zhang Y, Luo Y, Rao Y, Qu J, Gai X, Sun Y.   +7 more
europepmc   +1 more source

A Photothermal‐Responsive PRP‐Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A photothermal‐responsive engineered platelet‐rich plasma hydrogel (CNB‐ePRP) incorporated with thrombin‐functionalized composite nanobottle was developed, which enables in situ PRP activation, on‐demand growth factor release, multifunctionality, and personalized antimicrobial loading for treatment of diabetic wounds. The CNB‐ePRP hydrogel demonstrated
Wen‐Qiang Qu, Hui‐Yun Gu, Si‐Min Zeng, Chang‐Jiang Liu, Xiao Yan, Ting Pan, Chao Jian, Xian‐Zheng Zhang, Ai‐Xi Yu   +8 more
wiley   +1 more source

Depletion of all platelet integrins impacts hemostasis, thrombosis, and tumor metastasis. [PDF]

iScience
Janus-Bell E, Liboni C, Yakusheva A, Mittelheisser V, Mouriaux C, Bourdon C, Bochler L, Hyenne V, Garcia-Leon M, Lefebvre O, Goetz JG, Mangin PH.   +11 more
europepmc   +1 more source

Regressive Neuroblastoma: Widely Accepted, Underreported Histology

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Whole‐mount section of the regressed neuroblastoma within the adrenal gland, showing a loose, collagenous, and edematous stroma. ABSTRACT Neuroblastoma accounts for approximately 8% of all pediatric cancers and up to 15% of pediatric cancer‐related deaths in malignant cases; neuroblastoma is the most common malignancy in infancy.
Tom Membrez, Jim C. H. Wilde, Oliver Sanchez, Danai Papangelopoulou, Fabienne Gumy‐Pause, Anne‐Laure Rougemont   +5 more
wiley   +1 more source

Modulation of PI3K/AKT/mTOR signaling pathway by combined stem cell and phytochemical treatment improves metabolic and reproductive outcomes in PCOS. [PDF]

J Ovarian Res
Chen J, Zhang L, Gan J, Teng X, Huang X, Lv J, Li H.   +6 more
europepmc   +1 more source

Advanced Gastric Cancer Presenting as a Giant Subepithelial Lesion: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
A giant subepithelial lesion. ABSTRACT Gastric cancer may occasionally present with a subepithelial lesion‐like appearance. When a gastric gastrointestinal stromal tumor (GIST) is suspected preoperatively without definitive pathological confirmation, intraoperative frozen section analysis is recommended to prevent inappropriate surgical intervention.
Ji Sun, Qian Wang, Yuemei Hu, Ping Yin, Ziming Zhou, Hui Chen, Xiaoming Zhu   +6 more
wiley   +1 more source

Bottlebrush Polymer Templates for the Synthesis of Gold Nanostructures and their Applications as Photothermal Agents and SERS Substrates. [PDF]

Small Methods
Chauhan DS, Zhang H, Robert J, Chisanga M, Rabanel JM, Mekhjian D, Zaouter C, Phan QT, Raj W, Patskovsky S, Patten SA, Samarut É, Masson JF, Banquy X.   +13 more
europepmc   +1 more source

Development of CAR Exosomes Targeting FAP for the Treatment of Intrauterine Adhesion

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Engineered extracellular vesicles (EVs) have emerged as promising cell‐free platforms for immunomodulation and tissue repair. In this study, we generated EVs derived from chimeric antigen receptor (CAR) T cells targeting fibroblast activation protein (FAP) and investigated their biological and therapeutic functions.
Wenyan Fu, Kewen Qian, Hongru Ai, Yitan Zou, Yaping Zhou, Ruixue Mao, Jian Zhao, Changhai Lei, Shi Hu   +8 more
wiley   +1 more source

Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts. [PDF]

EMBO J
Peiffer R, Laverdeur E, Gaigneaux A, Boumahd Y, Gullo C, Rademaker G, Crake R, Lavergne A, Maloujahmoum N, Agirman F, Herfs M, Masamune A, Letellier E, Bellahcène A, Peulen O.   +14 more
europepmc   +1 more source