Results 121 to 130 of about 396,954 (353)

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

open access: yesNature Communications
Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course of tumorigenesis.
Christel F. A. Ramirez   +12 more
doaj   +1 more source

Modelling Immunological Memory [PDF]

open access: yesIn Silico Immunology, 83-108, 2006, 2010
Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of ...
arxiv  

The architecture of co-culture spheroids regulates tumor invasion within a 3D extracellular matrix [PDF]

open access: yesarXiv, 2020
Tumor invasion, the process by which tumor cells break away from their primary tumor and gain access to vascular systems, is an important step in cancer metastasis. Most current 3D tumor invasion assays consisted of single tumor cells embedded within an extracellular matrix (ECM). These assays taught us much of what we know today on how key biophysical
arxiv  

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

open access: yes, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D   +4 more
core  

MICA-129 dimorphism and soluble MICA are associated with the progression of multiple myeloma [PDF]

open access: yes, 2018
Natural killer (NK) cells are immune innate effectors playing a pivotal role in the immunosurveillance of multiple myeloma (MM) since they are able to directly recognize and kill MM cells.
Achour, Adnane   +18 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Correction to: CART cells are prone to Fas- and DR5-mediated cell death

open access: yesJournal for ImmunoTherapy of Cancer, 2018
After publication of this article [1], it was noticed that 3 authors were missed from the author list.
Benjamin O. Tschumi   +10 more
doaj   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

open access: yesMolecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

An introduction to the immune network [PDF]

open access: yesarXiv, 1995
In this paper, after a telegraphic introduction to modern immunology, we present a simple model for the idiotypic network among antibodies and we study its relevance for the maintenance of immunological memory. We also consider the problem of computing the memory capacity of such a model.
arxiv  

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