Results 151 to 160 of about 438,171 (330)

Immunology and immunotherapy in the complex treatment of malignant tumors

, 2021
Semiglazov Vf, A. I. Tseluiko, Ирина Балдуева, Т. Л. Нехаева, A. S. Artemyeva, Asel Kudaybergenova, Светлана Проценко, A.V. Novik Novik, В. В. Семиглазов, Р. В. Донских, Т. Yu. Semiglazova, Roman Pesotskiy, V. S. Apollonova, Petr Krivorotko, А. М. Belyaev   +14 more
openalex   +2 more sources

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

Advanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira, Fábio M. de Azevedo, Ingrid G. S. Lins, Janaína C. O. Crispim, Giovanna A. Lira, Rômulo S. Cavalcante, Ricardo Cobucci, Carolina O. Mendes‐Aguiar, Rafaela Torres Dantas Da Silva, Vinícius E. da Silva, Ryan C. Q. Aquino, Raimundo F. Araújo Júnior   +11 more
wiley   +1 more source

Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma

Frontiers in Immunology
BackgroundCisplatin (DDP) is a clinical first-line chemotherapy drug for hepatocellular carcinoma (HCC), but treatment is often ineffective due to drug resistance.
Yi Gong, Yi Gong, Yajun Xiong, Yuting Gao, Xiaoyong Song, Yanli Gong, Dan Wang, Zhihan Liu, Yanguang Yang, Yanguang Yang, Junlan Lu, Junlan Lu, Isabelle Xinyue Zou, Xinli Shi, Xinli Shi   +14 more
doaj   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. [PDF]

, 2008
Decreased expression of peroxisome proliferator activated receptor-gamma (PPARgamma) and high levels of the proinflammatory enzyme cyclooxygenase-2 (COX-2) have been observed in many tumor types.
Dubinett, Steven M, Hazra, Saswati, Mao, Jenny T, Peebles, Katherine A, Sharma, Sherven   +4 more
core  

Evodiamine inhibits colorectal cancer cell stemness by disturbing ubiquitin specific protease 4 mediated SOX9 stabilization

Discover Oncology
Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer worldwide. It is of great importance to explore new mechanisms and therapeutic targets.
Siqi Chen, Jinfeng Yang, Guangying Qi, Jiawei Zhao, Yujing Chen, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Zhiyuan Jian, Jiamin Jin   +9 more
doaj   +1 more source

Tumor immunology CRISPR screening: present, past, and future. [PDF]

Trends Cancer, 2022
Dong MB, Tang K, Zhou X, Zhou JJ, Chen S.   +4 more
europepmc   +1 more source

Basic Research and Recent Progress in Tumor Immunology

, 2016
M Takenoyama
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy. [PDF]

Front Immunol, 2022
de Alencar VTL, Figueiredo AB, Corassa M, Gollob KJ, Cordeiro de Lima VC.   +4 more
europepmc   +1 more source