Results 161 to 170 of about 3,283,768 (383)

CD44v, S1PR1, HER3, MET and cancer‐associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

FEBS Open Bio, EarlyView.
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano, Kouki Okita, Shogo Okazaki, Soshi Yoshimoto, Sachiko Masuko, Hideki Yagi, Kazunori Kato, Yoshihisa Tomioka, Kenichi Imai, Yoichi Hamada, Kazue Masuko, Kayoko Shimada‐Takaura, Noriaki Nagai, Hideyuki Saya, Tomio Arai, Toshiyuki Ishiwata, Takashi Masuko   +16 more
wiley   +1 more source

Basal cell adhesion molecule (BCAM) promotes mesothelial-to-mesenchymal transition and tumor angiogenesis through paracrine signaling

Cell Communication and Signaling
Background High expression of basal cell adhesion molecule (BCAM) is a hallmark of ovarian cancer (OC) progression. BCAM facilitates transcoelomic dissemination by promoting mesothelial cell clearance at peritoneal attachment sites of tumor cell ...
Suresh Sivakumar, Sonja Lieber, Raimund Dietze, Vanessa M. Beutgen, Eileen C. Sutor, Sophie Heidemann, Florian Finkernagel, Julia Teply-Szymanski, Andrea Nist, Thorsten Stiewe, Katrin Roth, Silke Reinartz, Johannes Graumann, Sabine Müller-Brüsselbach, Rolf Müller   +14 more
doaj   +1 more source

An introduction to the immune network [PDF]

arXiv, 1995
In this paper, after a telegraphic introduction to modern immunology, we present a simple model for the idiotypic network among antibodies and we study its relevance for the maintenance of immunological memory. We also consider the problem of computing the memory capacity of such a model.
arxiv  

IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8+ T cells [PDF]

, 2016
Immune responses to protein antigens involve CD4+ and CD8+ T cells, which follow distinct programs of differentiation. Naïve CD8 T cells rapidly develop cytotoxic T-cell (CTL) activity after T-cell receptor stimulation, and we have previously shown that ...
Fairbanks, L, Lovell, A, Mehta, H, Noble, A, Papaioannou, E   +4 more
core   +2 more sources

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D, Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Okada, Hideho   +4 more
core  

Dysregulation of Chemokine/Chemokine Receptor Axes and NK Cell Tissue Localization during Diseases. [PDF]

, 2016
Chemokines are small chemotactic molecules that play key roles in physiological and pathological conditions. Upon signaling via their specific receptors, chemokines regulate tissue mobilization and trafficking of a wide array of immune cells, including ...
Ali, Allegretti, Balabanian, Berahovich, Bernardini, Bernardini, Bielekova, Bolomsky, Bradfield, Broxmeyer, Burga, Calderon, Campbell, Campbell, Carlsten, Carrega, Carrega, Castriconi, Chan, Chiossone, Chuang, Clift, Contento, Cooper, Doncker, Eisenhardt, El-Sherbiny, Fehniger, Foxman, Gajewski, Gao, Gomez-Mouton, Gregoire, Gulino, Halama, Hanna, Hayakawa, Huntington, Huntington, Inngjerdingen, Ishibashi, Ju, Juelke, Kastrukoff, Kramp, Krug, Krumbholz, Lanier, Lode, Lopez-Verges, Lunemann, Mace, Maciejewski-Duval, Mailliard, Mantovani, Marcenaro, Marquardt, Martin, Martin-Fontecha, Martinez-Rodriguez, Mayol, Moustaki, Muller, Nagasawa, Nakashima, Nokihara, Ottaviani, Ouyang, O’Boyle, Pablos, Pachynski, Pak-Wittel, Parolini, Paust, Petit, Ponzetta, Ponzetta, Riva, Rodriguez-Martin, Romagnani, Sciume, Sechler, Serrano-Pertierra, Shimoda, Sohy, Sojka, Somanchi, Stabile, Stegmann, Stumm, Szpurka, Tham, Vanbervliet, Vandenbark, Vischer, Vitale, Watt, Watts, Wendel, Yokoyama, Zabel, Zlotnik   +101 more
core   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100

Mediators of Inflammation, 2015
We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor.
Víctor Toledano, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Marta Flandez, Enrique Álvarez, Aníbal Varela-Serrano, Ramón Cantero, Gema Valles, Francisco García-Rio, Eduardo López-Collazo   +9 more
doaj   +1 more source

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

Frontiers in Immunology, 2019
Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions ...
Thiago A. Patente, Mariana P. Pinho, Aline A. Oliveira, Gabriela C. M. Evangelista, Patrícia C. Bergami-Santos, José A. M. Barbuto, José A. M. Barbuto   +6 more
doaj   +1 more source