Results 201 to 210 of about 267,863 (253)
Advanced Science, EarlyView.ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen +22 more
wiley +1 more source
Advanced Science, EarlyView.A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming +9 more
wiley +1 more source
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2007
Advances in tumor immunology are supporting the clinical implementation of several immunological approaches to cancer in the clinical setting. However, the alternate success of current immunotherapeutic regimens underscores the fact that the molecular mechanisms underlying immune-mediated tumor rejection are still poorly understood.
MOCELLIN, SIMONE, LISE M, NITTI, DONATO
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Advances in tumor immunology are supporting the clinical implementation of several immunological approaches to cancer in the clinical setting. However, the alternate success of current immunotherapeutic regimens underscores the fact that the molecular mechanisms underlying immune-mediated tumor rejection are still poorly understood.
MOCELLIN, SIMONE, LISE M, NITTI, DONATO
+7 more sources
Current Opinion in Oncology, 1991
The underlying premise of tumor immunology is that the immune system is capable of recognizing cancer cells and that immune recognition can lead to rejection of tumors by the host. We focus on recent advances in tumor immunology in experimental systems, including the molecular identification of tumor antigens, studies of recognition of tumor cells by ...
C, Naftzger, A N, Houghton
openaire +2 more sources
The underlying premise of tumor immunology is that the immune system is capable of recognizing cancer cells and that immune recognition can lead to rejection of tumors by the host. We focus on recent advances in tumor immunology in experimental systems, including the molecular identification of tumor antigens, studies of recognition of tumor cells by ...
C, Naftzger, A N, Houghton
openaire +2 more sources
Mathematical Models and Methods in Applied Sciences, 2006
The aim of this paper is to discuss biological and computational models of tumor-immune system interactions. To this end we provid first a short introduction to the field of general immunology, then a more in-depth exposition of cancer immunology. Finally we discuss a first approach to vaccine that prevent tumor onset from a biological point of view ...
LOLLINI P. L +2 more
openaire +4 more sources
The aim of this paper is to discuss biological and computational models of tumor-immune system interactions. To this end we provid first a short introduction to the field of general immunology, then a more in-depth exposition of cancer immunology. Finally we discuss a first approach to vaccine that prevent tumor onset from a biological point of view ...
LOLLINI P. L +2 more
openaire +4 more sources
Immunology of genitourinary tumors
Urology, 1973Abstract A summary of basic tumor immunology is presented, including the evidence which supports the concept that urologic tumors are antigenic and that the host reacts against these tumors. Possible applications of urologic tumor immunology available to the clinician are discussed.
P, Guinan +5 more
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Immunology of Experimental Tumors
Annual Review of Medicine, 1964One of the most important advances in cancer biology of recent years is the conclusive demonstration that a variety of experimental tumors possess antigenicity capable of eliciting specific immune responses. This review will be restricted largely to those experimental systems in which the antigenic differences between tumor and host have been most ...
L J, OLD, E A, BOYSE
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Immunologic Nonresponsiveness to Tumors
Critical Reviews™ in Oncogenesis, 1998Over the past several years it has become clear that malignant cells express a variety of tumor associated antigens, and T cells reactive to these antigens have been identified. However, the T cells are not effective in rejecting tumors. In general, T cells that are not tolerized within the thymus have the potential to be rendered tolerant by one of ...
S J, Antonia, M, Extermann, R A, Flavell
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Immunology of intraocular tumors
American Journal of Ophthalmology, 2005The immune surveillance hypothesis was introduced over 30 years ago and proposed that neoplasms express novel antigens that subjected them to immune detection and elimination. In order for immune surveillance to be effective in controlling neoplasms, two requirements must be satisfied: 1) the tumor must arise in a body site that permits the induction ...
Jerry Y, Niederkorn, Shixuan, Wang
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The Thoracic and Cardiovascular Surgeon, 1990
Whereas abundant literature is available on mechanisms imposed by neoplastic diseases on the immune system, only few details are known about immunological parameters of autoreactive mechanisms directed against the heart. This report will focus on cardiac autoreactivity in patients with endomyocardial types of cardiac tumors (e.g.
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Whereas abundant literature is available on mechanisms imposed by neoplastic diseases on the immune system, only few details are known about immunological parameters of autoreactive mechanisms directed against the heart. This report will focus on cardiac autoreactivity in patients with endomyocardial types of cardiac tumors (e.g.
openaire +2 more sources