Results 241 to 250 of about 439,426 (292)
Advanced Science, EarlyView.RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song +11 more
wiley +1 more source
Advanced Science, EarlyView.A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding +6 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang +9 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
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2007
Advances in tumor immunology are supporting the clinical implementation of several immunological approaches to cancer in the clinical setting. However, the alternate success of current immunotherapeutic regimens underscores the fact that the molecular mechanisms underlying immune-mediated tumor rejection are still poorly understood.
MOCELLIN, SIMONE, LISE M, NITTI, DONATO
+6 more sources
Advances in tumor immunology are supporting the clinical implementation of several immunological approaches to cancer in the clinical setting. However, the alternate success of current immunotherapeutic regimens underscores the fact that the molecular mechanisms underlying immune-mediated tumor rejection are still poorly understood.
MOCELLIN, SIMONE, LISE M, NITTI, DONATO
+6 more sources
Current Opinion in Oncology, 1991
The underlying premise of tumor immunology is that the immune system is capable of recognizing cancer cells and that immune recognition can lead to rejection of tumors by the host. We focus on recent advances in tumor immunology in experimental systems, including the molecular identification of tumor antigens, studies of recognition of tumor cells by ...
C, Naftzger, A N, Houghton
openaire +5 more sources
The underlying premise of tumor immunology is that the immune system is capable of recognizing cancer cells and that immune recognition can lead to rejection of tumors by the host. We focus on recent advances in tumor immunology in experimental systems, including the molecular identification of tumor antigens, studies of recognition of tumor cells by ...
C, Naftzger, A N, Houghton
openaire +5 more sources
Mathematical Models and Methods in Applied Sciences, 2006
The aim of this paper is to discuss biological and computational models of tumor-immune system interactions. To this end we provid first a short introduction to the field of general immunology, then a more in-depth exposition of cancer immunology. Finally we discuss a first approach to vaccine that prevent tumor onset from a biological point of view ...
LOLLINI P. L +2 more
openaire +4 more sources
The aim of this paper is to discuss biological and computational models of tumor-immune system interactions. To this end we provid first a short introduction to the field of general immunology, then a more in-depth exposition of cancer immunology. Finally we discuss a first approach to vaccine that prevent tumor onset from a biological point of view ...
LOLLINI P. L +2 more
openaire +4 more sources
JAMA, 1997
Malignant tumors express antigens that may stimulate and serve as targets for antitumor immunity. Virally induced tumors usually contain integrated proviral genomes in theircellulargenomes and often express viral genome-encoded proteins that may stimulate specific host immune responses.
S, Shu +3 more
openaire +3 more sources
Malignant tumors express antigens that may stimulate and serve as targets for antitumor immunity. Virally induced tumors usually contain integrated proviral genomes in theircellulargenomes and often express viral genome-encoded proteins that may stimulate specific host immune responses.
S, Shu +3 more
openaire +3 more sources
DeckerMed Medicine, 2017
The immune system has effectively evolved to protect the host against foreign invaders, including bacterial, viral, and parasitic infiltrates. Less clear has been the interaction and the protective effects the immune system mounts against its own infiltrates: cancer cells. Here we consider the dynamic interactions between cancer and the associated host
Svetomir N Markovic +2 more
openaire +1 more source
The immune system has effectively evolved to protect the host against foreign invaders, including bacterial, viral, and parasitic infiltrates. Less clear has been the interaction and the protective effects the immune system mounts against its own infiltrates: cancer cells. Here we consider the dynamic interactions between cancer and the associated host
Svetomir N Markovic +2 more
openaire +1 more source
JAMA: The Journal of the American Medical Association, 1992
Wulf Dröge, Margot Zöller
openaire +3 more sources
Wulf Dröge, Margot Zöller
openaire +3 more sources