Results 221 to 230 of about 87,711 (271)

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

Risky Remedy: Rasburicase-Induced Methemoglobinemia in Tumor Lysis Syndrome Complicated by G6PD Deficiency. [PDF]

Cureus
Peshin S, Singal S, Moka N.
europepmc   +1 more source

Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Enzyme assays and computational analyses reveal that human histidine methyltransferases SETD3 and METTL9 have a capacity to catalyze histidine ethylation in the presence of synthetic or in situ produced S‐adenosylethionine (AdoEth) and Se‐adenosylselenoethionine (AdoSeEth) cosubstrates.
Jordi C. J. Hintzen, Zhimei Yu, Sadaf Ahmad, Xin Zhang, Yuan–Yuan Zhao, Hao Deng, Leonie Schütz, Marija Ram, Julia Z. Kaminska, Jakub Drozak, Elmar Weinhold, Hong Guo, Andrea Rentmeister, Ping Qian, Jasmin Mecinović   +14 more
wiley   +1 more source

Tumor Lysis Syndrome in a 30-Year-Old Male With Metastatic Seminoma: A Case Report. [PDF]

Cureus
Sivanandam A, Viswanathan D, Shah A, De Silva P.   +3 more
europepmc   +1 more source

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 12, Page 3252-3267, 15 June 2026.
What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Karen J. Scott, Emma J. West, Rebecca J. Brownlie, Fay Ismail, Christy Ralph, Thomas Heineman, Matt Coffey, Alan A. Melcher, Alison Taylor, Salvatore Papa, Adel Samson   +10 more
wiley   +1 more source

Tumor Lysis Syndrome with Venetoclax/Carfilzomib/Dexamethasone for Relapsed/Refractory Multiple Myeloma: A Case Report. [PDF]

Reports (MDPI)
Fankhauser R, Lu A, Kassim A, Biltibo E.
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Tumor Lysis Syndrome in an Elderly Male With Newly Diagnosed Large Cell B-Lymphoma Despite Prophylactic Treatment. [PDF]

Cureus
Reid ES, Nix H, Ibrahim M, Maddux A.
europepmc   +1 more source

Small cell lung cancer case report: acute tumor lysis syndrome after chemotherapy and management strategies for high-risk patients. [PDF]

Int J Emerg Med
Han Y, Yue P, Yuan Z.
europepmc   +1 more source

Spontaneous tumor lysis syndrome in an adult with alveolar rhabdomyosarcoma: a challenging diagnosis. [PDF]

Oxf Med Case Reports
Abufara AA, Alsahouri MI, Alsalah QA, Arafat H, Hammouri AG, Aqeel BA.   +5 more
europepmc   +1 more source