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The Indian Journal of Pediatrics, 2012
Tumor lysis syndrome (TLS) refers to the constellation of deranged metabolic state, characterized by hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, and/or azotemia, secondary to rapid breakdown of tumor cells. It is a life threatening emergency that typically follows administration of chemotherapy or may be spontaneous.
Aruna, Rajendran +3 more
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Tumor lysis syndrome (TLS) refers to the constellation of deranged metabolic state, characterized by hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, and/or azotemia, secondary to rapid breakdown of tumor cells. It is a life threatening emergency that typically follows administration of chemotherapy or may be spontaneous.
Aruna, Rajendran +3 more
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Tumor Lysis Syndrome in Solid Tumors
Supportive Cancer Therapy, 2005Tumor lysis syndrome (TLS) consists of acute hyperuricemic nephropathy, hyperphosphatemia, hypocalcemia, hyperkalemia, and increased serum creatinine. It can be part of the disease presentation, especially in aggressive hematologic malignancies, or a part of the chemotherapy response. There are relatively few reports of TLS in solid tumors.
Frank E, Mott +3 more
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Seminars in Hematology, 2001
Tumor lysis syndrome (TLS) is a constellation of metabolic disturbances observed in tumors with high cell turnover. It is associated with significant morbidity and mortality. TLS is characterized by the increased release of intracellular contents (uric acid, potassium, phosphorus) into the extracellular compartment, which can overwhelm the body's ...
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Tumor lysis syndrome (TLS) is a constellation of metabolic disturbances observed in tumors with high cell turnover. It is associated with significant morbidity and mortality. TLS is characterized by the increased release of intracellular contents (uric acid, potassium, phosphorus) into the extracellular compartment, which can overwhelm the body's ...
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Tumor lysis syndrome in elderly
Critical Reviews in Oncology/Hematology, 2007The majority of cancers occur in adults over the age of 65, with about 70% of all cancer deaths in this population. Tumor lysis syndrome (TLS) is a complication of hematological and others malignancies, caused by massive tumor cell lysis due to chemotherapy, immunotherapy, radiotherapy.
PUMO V, SCIACCA D, MALAGUARNERA, Mariano
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Seminars in Oncology Nursing, 1999
To review the pathophysiology, clinical manifestations, and management of tumor lysis syndrome.Published articles, case reports, and book chapters on tumor lysis syndrome.Tumor lysis syndrome is a very serious and sometimes life-threatening complication of cancer treatment. Identification of patients at risk and initiation of preventative interventions
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To review the pathophysiology, clinical manifestations, and management of tumor lysis syndrome.Published articles, case reports, and book chapters on tumor lysis syndrome.Tumor lysis syndrome is a very serious and sometimes life-threatening complication of cancer treatment. Identification of patients at risk and initiation of preventative interventions
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Seminars in Oncology, 2001
Abstract The electrolyte abnormalities and metabolic derangements associated with ATLS are a serious consequence in patients with both hematologic malignancies and solid tumors. While concern is primarily for those with highly proliferative hematopoietic disorders following treatment with exquisitely responsive chemotherapy, the practitioner should ...
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Abstract The electrolyte abnormalities and metabolic derangements associated with ATLS are a serious consequence in patients with both hematologic malignancies and solid tumors. While concern is primarily for those with highly proliferative hematopoietic disorders following treatment with exquisitely responsive chemotherapy, the practitioner should ...
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Overview of tumor lysis syndrome
Seminars in Oncology Nursing, 2002To provide a general overview of tumor lysis syndrome (TLS) focusing on the incidence, epidemiology, and patient outcomes associated with the syndrome; review the role of the oncology nurse in impacting patient outcomes and identify evolving issues relating to TLS.Primary and tertiary literature related to TLS and clinical practice experience.Issues ...
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Incidence and Pathogenesis of Tumor Lysis Syndrome
2004Tumor lysis syndrome (TLS) is a constellation of metabolic disturbances that may be observed in patients with malignancies. Clinically significant TLS can occur spontaneously, but most often is seen 48-72 h after initiation of cancer treatment.
LOCATELLI F, ROSSI, Francesca
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JAMA: The Journal of the American Medical Association, 1983
To the Editor.— The recent report by Vogelzang et al (1983;249:513) of tumor lysis syndrome after chemotherapy for small-cell bronchogenic carcinoma was of great interest. We would like to report an additional case recently seen in our facility. Report of a Case.— A 78-year-old man was found to have small-cell carcinoma of the lung with multiple ...
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To the Editor.— The recent report by Vogelzang et al (1983;249:513) of tumor lysis syndrome after chemotherapy for small-cell bronchogenic carcinoma was of great interest. We would like to report an additional case recently seen in our facility. Report of a Case.— A 78-year-old man was found to have small-cell carcinoma of the lung with multiple ...
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Gan to kagaku ryoho. Cancer & chemotherapy, 2009
Recently, the ASCO guideline has added TLS. Prevention and recognition of the disease and state are important. Molecular targeting drugs, small molecule tyrosine kinase inhibitors and monoclonal antibodies induced rapid regression of the tumors and carry a risk of TLS.
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Recently, the ASCO guideline has added TLS. Prevention and recognition of the disease and state are important. Molecular targeting drugs, small molecule tyrosine kinase inhibitors and monoclonal antibodies induced rapid regression of the tumors and carry a risk of TLS.
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