Results 151 to 160 of about 580,024 (350)

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy

, 2004
Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with
Jamie G. Evans, Gary Warnes, Mauri, C, Isenberg, DA, Warnes, G, Samantha Moore, Michael R. Ehrenstein, Evans, JG, Moore, S, Singh, A, David A. Isenberg, Claudia Mauri, Ehrenstein, MR, Animesh Singh   +13 more
core   +1 more source

Can the interleukin TNF-α be used as a biomarker for pulp necrosis?

Acta Odontologica Scandinavica
N ...
Carlos Wesley Lopes Brasil da Silva, Beatriz Melare de Oliveira, Jheinis Stefany Pascuineli Duarte, Thalya Fernanda Hortsh Maltarollo, Henrico Badaoui Strazzi-Sahyon, Gustavo Sivieri-Araújo   +5 more
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Osteoimmunology of tumor necrosis factor-alpha, IL-6, and RANTES/CCL5: a review of known and poorly understood inflammatory patterns in osteonecrosis

, 2018
Johann Lechner,1 Tatjana Rudi,2 Volker von Baehr3 1Clinic for Integrative Dentistry, Munich 81547, Germany; 2Institute for Epidemiological Studies, Berlin 10709, Germany; 3Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ
Lechner J, Rudi T, von Baehr V
core  

Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.

Arthritis & Rheumatism, 1998
R. Maini, F. Breedveld, J. Kalden, J. Smolen, D. Davis, J. Macfarlane, C. Antoni, B. Leeb, M. Elliott, J. Woody, T. Schaible, M. Feldmann   +11 more
semanticscholar   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease

, 2018
Deenaz Zaidi,1,2 Hien Q Huynh,1 Matthew W Carroll,1 Shairaz Baksh,1,3,4 Eytan Wine1,2,5 1Department of Pediatrics, 2Department of Medicine, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR), 3Department of ...
Zaidi D, Huynh HQ, Carroll MW, Baksh S, Wine E   +4 more
core