Results 41 to 50 of about 29,503 (186)

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]

, 2017
Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David, Cannon, Paula M, Chateau, Morgan, Karn, Jonathan, Llewellyn, George N   +4 more
core   +1 more source

Tumor pardo multifocal como manifestación inicial de carcinoma paratiroideo. Presentación de caso

Revista colombiana de radiología, 2020
 El carcinoma de paratiroides es una causa excepcional de hiperparatiroidismo primario. Los tumores pardos se desarrollan como manifestaciones esqueléticas de hiperparatiroidismo primario en el contexto de una enfermedad avanzada. Son lesiones óseas líticas, altamente vasculares con un proceso celular reparador en lugar de un proceso neoplásico. Pueden
María Berenice Reyes, Silvia Lissett Espinoza Alvarado, Didier Armando Robles López, Carlos Rivera Argeñal, Yaritza Turcios   +4 more
openaire   +2 more sources

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types [PDF]

, 2017
In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Bose, Ron, Kumar, Runjun D
core   +2 more sources

Tumor pardo en el maxilar a consecuencia de un adenoma paratiroideo: reporte de un caso

Revista Odontológica Mexicana Órgano Oficial de la Facultad de Odontología UNAM, 2022
El tumor pardo es una lesión que se desarrolla ocasionalmente en pacientes con hiperparatiroidismo y ocasionalmente se presenta en maxilar y mandíbula, son tumores que se deben diferenciar de las lesiones de células gigantes, por lo que es necesario realizar el diagnóstico diferencial con el granuloma central de células gigantes mediante una adecuada ...
Gabriela Vilar Pineda, Rafael Ruiz Rodríguez, Juan Carlos López Noriega   +2 more
openaire   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer. [PDF]

, 2019
MTOR associated protein, eak-7 homolog (mEAK-7), activates mechanistic target of rapamycin (mTOR) signaling in human cells through an alternative mTOR complex to regulate S6K2 and 4E-BP1.
Fox, Alexandra Lucienne, Haidar, Fatima Sarah, Kim, Jin Koo, Krebsbach, Paul H, Mendonça, Daniela Baccelli, Nguyen, Joe Truong, Ray, Connor   +6 more
core  

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Prospective implementation of the HCT frailty scale in adults with lymphoproliferative syndromes candidates for autologous haematopoietic stem cell transplantation: Results from a multicentre GETH‐TC study

British Journal of Haematology, EarlyView.
Summary This prospective study evaluated the incidence and dynamics of frailty in 156 adults with lymphoproliferative syndromes undergoing autologous haematopoietic stem cell transplantation (HSCT). Frailty was assessed using the haematopoietic cell transplantation (HCT) frailty scale in patients from 15 Spanish institutions at initial consultation ...
Javier Cornago, Mónica Baile, Marina Acera, Laura Fox, María del Mar Pérez‐Artigas, Ana Santamaría, María del Carmen Quintela, Andrés Sánchez‐Salinas, Joaquina M. Salmerón, Verónica Illana, Zahra Abdallahi‐Lefdil, Laura Pardo, Laura Solán, José Luis López‐Lorenzo, Sara Fernández‐Luis, Leddy Patricia Vega, Sara Villar, Patricia Beorlegui‐Murillo, Mónica Molina, Albert Esquirol, Isabel Izquierdo, Julia Ribes, Alberto Mussetti, Esperanza Lavilla, Olga Alda, Javier López‐Marín, Leyre Bento, Silvia Filaferro, Pascual Balsalobre, Anna Sureda, María Queralt Salas   +30 more
wiley   +1 more source

The burden of COVID‐19 in hospitalized people with diabetes mellitus in Brazil: Insights from four years of the pandemic

Diabetic Medicine, EarlyView.
Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo, Bianca Aparecida Siqueira, Luiz Felipe Azevedo Marques, Lucas Silva Mello, Fernando Augusto Lima Marson   +4 more
wiley   +1 more source

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources