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Branched Neurotensin for Tumor Targeting
2010Introduction One of the major problems in classic chemotherapy is the non-specific toxicity of most anticancer agents against normal cells. The specific targeting of tumors has been the main challenge in research on cancer therapy and diagnosis.
FALCIANI C. +5 more
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Cancer remains a global health challenge, with conventional treatments often limited by toxicity and specificity. Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment by modifying T cells to target tumor antigens, showing significant success in hematological malignancies like acute lymphoblastic leukemia and diffuse large ...
Safiya Mehraj, Shazia Ali
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Safiya Mehraj, Shazia Ali
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Tumor-Targeting Theranostic Polymers
LangmuirTheranostic polymers have emerged as a versatile platform in cancer nanomedicine, integrating therapeutic and imaging functionalities to overcome challenges in oncology. Featuring diverse architectures such as linear polymers, dendrimers, star-like polymers, and bottle-brush polymers, these systems enable tumor-targeted drug delivery, real-time imaging,
Ying Wei, Mingfeng Wang
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MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting.
TIPS - Trends in Pharmacological Sciences, 2018Matrix metalloproteinases (MMPs) are major extracellular enzymes involved in cancer initiation, progression, and metastasis. MMPs are widely used as cancer biomarkers and therapeutic targets.
Qing Yao, Longfa Kou, Ying Tu, Lin Zhu
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Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy.
Research in Microbiology, 2019Abnormal blood vessels and hypoxic and necrotic regions are common features of solid tumors and related to the malignant phenotype and therapy resistance.
Ruijuan Li +10 more
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A Highly Efficient Tumor‐Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism
Advances in Materials, 2019Efficient tumor targeting has been a great challenge in the clinic for a very long time. The traditional targeting methods based on enhanced permeability and retention (EPR) effects show only an ≈5% targeting rate.
Zhendong Lei +11 more
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Drugs of the Future, 2006
Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
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Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
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2020
The rising prominence of cancer as a leading cause of death reflects therapeutic predicament over malignancy, leading to intensive efforts for tumor treatment. Anticancer precision medicine has shown great progress in recent years, holding promise to reduce side effects and improve treatment outcome.
Min Liu, Weiyue Lu
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The rising prominence of cancer as a leading cause of death reflects therapeutic predicament over malignancy, leading to intensive efforts for tumor treatment. Anticancer precision medicine has shown great progress in recent years, holding promise to reduce side effects and improve treatment outcome.
Min Liu, Weiyue Lu
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2020
Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The development of tumor hypoxia can be viewed as an imbalance between oxygen supply and demand. Tumor hypoxia significantly impacts tumor radiosensitivity and subsequently leads to poor clinical outcomes in patients treated with radiation therapy.
Michael Skwarski +4 more
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Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The development of tumor hypoxia can be viewed as an imbalance between oxygen supply and demand. Tumor hypoxia significantly impacts tumor radiosensitivity and subsequently leads to poor clinical outcomes in patients treated with radiation therapy.
Michael Skwarski +4 more
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Brain and other central nervous system tumor statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Kimberly D Miller +2 more
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