Results 211 to 220 of about 3,547,100 (335)

Endothelial cell-specific LAT1 ablation normalizes tumor vasculature. [PDF]

JCI Insight
Suehiro JI, Kimura T, Fukutomi T, Naito H, Kanki Y, Wada Y, Kubota Y, Takakura N, Sakurai H.   +8 more
europepmc   +1 more source

Cross-Modality Imaging of Murine Tumor Vasculature-a Feasibility Study. [PDF]

Mol Imaging Biol, 2021
Zopf LM, Heimel P, Geyer SH, Kavirayani A, Reier S, Fröhlich V, Stiglbauer-Tscholakoff A, Chen Z, Nics L, Zinnanti J, Drexler W, Mitterhauser M, Helbich T, Weninger WJ, Slezak P, Obenauf A, Bühler K, Walter A.   +17 more
europepmc   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist. [PDF]

Cancer Immunol Immunother
Magdalena JB, Justyna C, Joanna C, Ryszard S, Alina D, Dorota SL, Ewelina P, Sybilla M, Tomasz C.   +8 more
europepmc   +1 more source

Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma. [PDF]

Front Oncol, 2022
Ribatti D, Pezzella F.
europepmc   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Endothelial STING-JAK1 interaction promotes tumor vasculature normalization and antitumor immunity. [PDF]

J Clin Invest
Zhang H, Wang Z, Wu J, Zheng YQ, Zhao Q, He S, Jiang H, Jiang C, Wang T, Liu Y, Cui L, Guo H, Yi J, Jin H, Xie C, Li M, Li J, Wang X, Xia L, Zhang XS, Xia X.   +20 more
europepmc   +1 more source

Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody. [PDF]

J Immunother Cancer, 2023
Park JA, Espinosa-Cotton M, Guo HF, Monette S, Cheung NV.   +4 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells. [PDF]

Acta Pharm Sin B
Zhao C, Wang W, Huang Z, Wan Y, Xu R, Zhang J, Zhao B, Wang K, Wen S, Zhong Y, Huang D, Chen W.   +11 more
europepmc   +1 more source