Results 291 to 300 of about 3,547,100 (335)

Antibody-based targeting of the tumor vasculature

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2007
Conventional cytotoxic therapies of cancer often suffer from a lack of specificity, leading to a poor therapeutic index and considerable toxicities to normal organs. An elegant way to overcome the disadvantages of conventional tumor therapy is the selective delivery of therapeutics to the tumor site by their conjugation to a carrier molecule specific ...
Christoph, Schliemann, Dario, Neri
openaire   +2 more sources

Antibody Targeting of Tumor Vasculature

2002
For many years the idea of the “magic bullet” approach to target cells in the treatment of cancer and other pathological conditions has been a tempting scenario. One such approach is to develop monoclonal antibodies (MAbs) against defined cell-surface markers and use these antibodies to direct cytotoxic agents to specific cells.
J Wilson, David C West, Philip E Thorpe
openaire   +1 more source

Improved tumor vasculature for immunotherapy

Science, 2019
Cancer Dysfunctional vasculature in tumors reduces oxygenation and access to nutrients and prevents immune cell infiltration, which can limit immunotherapy. Cellular components of blood and lymphatic vessels can also directly modulate antitumor immune responses.
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Chapter 7 Molecular Imaging of Tumor Vasculature

2008
Cancer, with more than 10 million new cases a year worldwide, is the third leading cause of death in developed countries. One critical requirement during cancer progression is angiogenesis, the formation of new blood vessels. Structural and functional imaging of tumor vasculature has been studied using various imaging modalities such as magnetic ...
Weibo, Cai, Sanjiv S, Gambhir, Xiaoyuan, Chen   +2 more
openaire   +2 more sources

There will be blood: targeting tumor vasculature

Blood, 2009
Extradomain B of fibronectin (ED-B FN) is expressed in the vasculature of hematopoietic malignancies and appears to be an effective target for monoclonal antibody–based therapies.
Nathan, Fowler, Anas, Younes
openaire   +2 more sources

Targeting Tumor Vasculature: Reality or a Dream?

Journal of Drug Targeting, 2002
In recent years, it has become clear that angiogenesis is important not only in physiological processes such as embryonic development, the female reproductive cycle, wound healing, and organ and tissue regeneration but also in pathological processes such as tumor progression and metastasis (Hanahan and Folkman, 1996).
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

Science, 2005
R. Jain
semanticscholar   +1 more source

Tumor Vasculature Targeted Therapies

Biochemical Pharmacology, 1998
Molema, G, Meijer, D.K F, de Leij, Lou
openaire   +2 more sources

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

Nature Medicine, 2001
R. Jain
semanticscholar   +1 more source

Brain and other central nervous system tumor statistics, 2021

Ca-A Cancer Journal for Clinicians, 2021
Kimberly D Miller, Quinn T Ostrom, Carol Kruchko Ba   +2 more
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