Results 131 to 140 of about 1,039,582 (299)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Correlación anatomoecográfica de la infiltración tumoral parietal en el cáncer de recto
Cirugía del Uruguay, 1994 Entre noviembre del 89 y octubre del 91, se estudiaron 96 pacientes con patología rectal, por ecografía endoluminal. En ese período se evaluaron 63 tumores, con 40 casos que cumplieron con los criterios de inclusión que se publican en este trabajo.
William Fernández +4 more
doaj
Effect of neopterin and 7,8‐dihydroneopterin on tumor necrosis factor‐α induced programmed cell death [PDF]
, 1995 Gabriele Baier-Bitterlich +8 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Neoplasma de colon transverso Fistulizado en el ciego
Cirugía del Uruguay, 1988 Se presenta un neoplasma del colon transverso derecho flstulizado en el ciego, variedad anatómica poco frecuente en las estadísticas extranjera y nacional consultada, con un "Second look" a los 5 meses que no mostró diseminación metastásica y con buena ...
Aída Cresseri +2 more
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Cirugía del Uruguay, 1989 Un regastrectomizado por cáncer de muñón gástrico presentó una doble fístula colecisto-colónica precedida de un íleo-biliar y obstrucción por cuerpo extraño intraluminal que fue tratada con parto al colon.
José Praderi +5 more
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source