Results 121 to 130 of about 490,488 (261)

Maternal Methyl Donor Nutrients Modulate Developmental Genes in Mammary Tumors. [PDF]

Biology (Basel)
Mabasa L, Kotze A, Johnson R, Ramharack P, Omoruyi SI, Gabuza KB, Sharma J, Willmer T.   +7 more
europepmc   +1 more source

Tumorigenesis [PDF]

, 2020
openaire   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Retraction: Long Noncoding RNA (lncRNA) HOTAIR Affects Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer by Upregulating miR-613. [PDF]

Oncol Res
Oncology Research Editorial Office.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer. [PDF]

Cell Death Dis
Searle J, Menotti M, McDaid WJ, Baker MJ, Chaturvedi A, Ginn L, Reed H, Carter M, Blackhall F, Lindsay CR, Malliri A.   +10 more
europepmc   +1 more source

Cyclooxygenase Isoforms in Tumorigenesis

Periodicum biologorum, 2010
Cyclooxygenases (COXs) are the key enzymes in prostanoid biosynthetic pathway. Prostanoids act as local hormones and they are involved in numerous normal physiological proceses but also in the development of various diseases. COXs are present in three isoforms: COX1, COX2 and COX3. COX1 is usually involved in maintaining the physiological conditions of
openaire   +3 more sources

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Impact of chronic low-dose external gamma- and internal tritium beta-irradiation on the gut microbiome in the context of intestinal tumorigenesis in <i>Apc^Min/+</i> mice. [PDF]

mSystems
Laakso H, Hashem Taha M, Flegal M, Surette J, Mysara M, Klokov D.   +5 more
europepmc   +1 more source