Results 91 to 100 of about 155,806 (387)

SIRT2‐mediated inactivation of p73 is required for glioblastoma tumorigenicity

EMBO Reports, 2018
Glioblastoma is one of the most aggressive forms of cancers and has a poor prognosis. Genomewide analyses have revealed that a set of core signaling pathways, the p53, RB, and RTK pathways, are commonly deregulated in glioblastomas.
Kosuke Funato, Tomoatsu Hayashi, Kanae Echizen, L. Negishi, Naomi Shimizu, Ryo Koyama-Nasu, Y. Nasu‐Nishimura, Y. Morishita, V. Tabar, T. Todo, Y. Ino, A. Mukasa, Nobuhito Saito, T. Akiyama   +13 more
semanticscholar   +1 more source

Random matrix analysis of localization properties of Gene co-expression network [PDF]

, 2010
We analyze gene co-expression network under the random matrix theory framework. The nearest neighbor spacing distribution of the adjacency matrix of this network follows Gaussian orthogonal statistics of random matrix theory (RMT). Spectral rigidity test
A. J. Butte, Baowen Li, Béla Bollobás, Gábor Vattay, H. Göhlmann, K. Zyczkowski, M. L. Mehta, Norbert Solymosi, Sarika Jalan   +8 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Analysis of L Antigen Family Member 3 as a Potential Biomarker and Therapeutic Target Associated With the Progression of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundHepatocellular carcinoma (HCC) is the third cause of cancer-related deaths worldwide. L antigen family member 3 (LAGE3) is a prognostic biomarker and associated with progression in a variety of tumors.
Qianhui Chen, Xinyu Lu, Jiayi Xie, Na Ma, Weikang Xu, Zhiming Zhang, Xuan Huang, Hongyan Liu, Jinlin Hou, Xiaoyong Zhang, Wei Zhu   +10 more
doaj   +1 more source

Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation

Cell Death and Disease, 2018
Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles and contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability to self-renew, differentiate into heterogeneous types of ...
Zhennan Tao, Tao Li, Haiwen Ma, Yihan Yang, Chen Zhang, Long Hai, Peidong Liu, F. Yuan, Jiabo Li, L. Yi, Luqing Tong, Yingshuai Wang, Yang Xie, Hao-lang Ming, Sheng-ping Yu, Xuejun Yang   +15 more
semanticscholar   +1 more source

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease [PDF]

, 2014
R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases.
Alarcón, Balbino, Bustelo, Xosé R., Cañamero, Marta, de Alava, Enrique, Dosil, Mercedes, Larive, Ramon, Menacho Márquez, Mauricio Ariel, Moriggi, Giulia   +7 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism

Nature Genetics, 2016
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas.
P. Bandopadhayay, P. Bandopadhayay, L. Ramkissoon, P. Jain, G. Bergthold, G. Bergthold, J. Wala, J. Wala, Rhamy Zeid, S. Schumacher, S. Schumacher, Laura Urbanski, Ryan O’Rourke, Ryan O’Rourke, William J. Gibson, William J. Gibson, K. Pelton, S. Ramkissoon, Harry J Han, Yuankun Zhu, N. Choudhari, Amanda Silva, Amanda Silva, Katie L. Boucher, Rosemary E. Henn, Y. J. Kang, David Knoff, B. Paolella, B. Paolella, A. Gladden-Young, P. Varlet, M. Pages, Peleg Horowitz, Alexander J. Federation, H. Malkin, A. Tracy, Sara Seepo, M. Ducar, P. Hummelen, M. Santi, A. Buccoliero, M. Scagnet, D. Bowers, C. Giannini, S. Puget, C. Hawkins, U. Tabori, Á. Klekner, L. Bognár, P. Burger, C. Eberhart, F. Rodriguez, D. Hill, S. Mueller, D. Haas-Kogan, D. Haas-Kogan, J. Phillips, S. Santagata, C. Stiles, J. Bradner, J. Bradner, N. Jabado, A. Goren, J. Grill, A. Ligon, L. Goumnerova, A. Waanders, P. Storm, M. Kieran, Keith L. Ligon, Keith L. Ligon, R. Beroukhim, R. Beroukhim, A. Resnick   +73 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA H19

Cells, 2020
Cancer stem cells (CSCs) represent a rare population of tumor cells that exhibit stem cell properties with the abilities of self-renewal and differentiation.
Clément Lecerf, Evodie Peperstraete, Xuefen Le Bourhis, Eric Adriaenssens   +3 more
doaj   +1 more source