Results 101 to 110 of about 13,396 (145)
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Saccharin Metabolism and Tumorigenicity
Science, 1979Exposure of male Charles River CD1 rats to a 5 percent saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (< 0.4 percent of the oral dose) of tritiated saccharin in vivo.
T W, Sweatman, A G, Renwick
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Journal of Applied Toxicology, 1984
AbstractPolycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents.
Michelle V. Buchanan +2 more
exaly +3 more sources
AbstractPolycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents.
Michelle V. Buchanan +2 more
exaly +3 more sources
Actin synthesis in tumorigenic and non-tumorigenic human hybrid cells
Journal of Cell Science, 1985ABSTRACT We have previously shown that the total actin content of tumorigenic HeLa/fibroblast somatic cell hybrids is significantly lower than that of the non-tumorigenic hybrid cells. A measure of actin synthesis, relative to total protein synthesis, was obtained for these cells to determine whether the reduced actin content of the ...
L R, Gowing, R L, Tellam, M R, Banyard
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International Journal of Gynecology & Obstetrics, 1979
This report presents a review of tumors, except those of pituitary, that have been reported to occur in women taking combined oral contraceptive preparations. Pathologic features, both gross and microscopic, and differential diagnosis are emphasized. Particular attention is given to tumors of the liver: focal nodular hyperplasia (hepatic hamartoma) and
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This report presents a review of tumors, except those of pituitary, that have been reported to occur in women taking combined oral contraceptive preparations. Pathologic features, both gross and microscopic, and differential diagnosis are emphasized. Particular attention is given to tumors of the liver: focal nodular hyperplasia (hepatic hamartoma) and
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Pluripotency and tumorigenicity
Nature Genetics, 2002Pluripotent stem cells are essential for embryonic development and regeneration of adult tissues. But when the molecular pathways that control stem cells go awry, the result can often be the development of tumors. Wnt signaling mediated by the intracellular transducer β-catenin and the tumor suppressor APC (adenomatosis polyposis coli) is pivotal in ...
Joshua M. Brickman, Thomas G. Burdon
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STEM CELLS, 1994
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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Dynamics of receptor trafficking in tumorigenicity
Trends in Cell Biology, 2012The transport and sorting of cell surface receptors into membrane-bound intracellular compartments is crucial for cellular homeostasis. Defects in receptor trafficking are associated with several diseases, including cancer. Recent advances in our understanding of mechanisms that control receptor trafficking have highlighted the involvement of membrane ...
Christine A, Parachoniak, Morag, Park
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Pro-tumorigenic AMPK in glioblastoma
Nature Cell Biology, 2018AMPK is a key metabolic sensor promoting cellular energy homeostasis under low-nutrient conditions and other stresses. However, its role in cancer is context-dependent and not fully understood. A study now shows that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.
Nektaria Maria, Leli +1 more
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Homogeneously staining regions and tumorigenicity
International Journal of Cancer, 1983AbstractA homogeneously staining region (HSR), a chromosome abnormality associated with gene amplification, was found to increase in length coincident with an enhancement in tumorigenicity when cells from a human retinoblastoma cell line were serially passaged in athymic (nu/nu) mice.
F, Gilbert +4 more
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Raman Spectroscopy and Factor Analysis of Tumorigenic and Non-Tumorigenic Cells
Applied Spectroscopy, 2002Raman spectra, measured for viable suspensions of M1 and MR1 cells, demonstrate spectral differences correlating with an increased protein and phospholipid content relative to DNA in the MR1 cells. The M1 and MR1 cell lines consist of rat fibroblast cells that have been transfected with a gene causing immortality, and the MR1 line has been further ...
Kristin M. Omberg +5 more
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