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, 2012 The biological functions of the BC047440 gene highly expressed by hepatocellular carcinoma (HCC) are unknown. The objective of this study was to reconstruct antisense eukaryotic expression vectors of the gene for inhibiting HepG2 cell proliferation and ...
Zheng Wang +6 more
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Tumorigenicity of Polyoma Virus in Hamsters
Cold Spring Harbor Symposia on Quantitative Biology, 1980 M A, Israel +5 more
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Safety assessment of rat embryonic fraction for in vivo regenerative therapy
Biology OpenSivarama Prasad Darsi +12 more
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Bioengineering, 2023 Stem cells hold promise in regenerative medicine due to their ability to proliferate and differentiate into various cell types. However, their self-renewal and multipotency also raise concerns about their tumorigenicity during and post-therapy.
Zongjie Wang
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Lumican, pro-tumorigenic or anti-tumorigenic: A conundrum
Clinica Chimica Acta, 2021The extracellular matrix (ECM) consists of a myriad of structural and signaling molecules which potentially regulate cell function and homeostasis. Lumican, a class II SLRP (small leucine rich proteoglycan) is a ubiquitous ECM component which not only organizes the collagen based structural matrix, but also modulates cell proliferation signals as ...
Sandeep Appunni +9 more
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Suppression of Tumorigenicity in Cybrids
Journal of Supramolecular Structure and Cellular Biochemistry, 1981AbstractWe investigated cytoplasmic control of tumorigenicity in cybrids. Cytoplasts derived from nontumorigenic cells were fused to the highly tumorigenic 984 Cl 10–15 cell line derived from a murine teratoma. The resultant cybrids did not retain the tumorigenicity of the original cell line.
Jerry W Shay, Mike A Clark
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An Index of Tumorigenic Potency
Biometrics, 1993A new index of tumorigenic potency is derived using a survival-adjusted quantal response estimator given by Bailer and Portier (1988, Biometrics 44, 417-431). The small-sample bias and mean squared error properties of this estimator are explored using computer simulations of animal carcinogenicity experiments and are compared to the characteristics of ...
Bailer, A. John, Portier, Christopher J.
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Trending topics of SIRT1 in tumorigenicity
Biochimica et Biophysica Acta (BBA) - General Subjects, 2021Carcinogenesis is governed by a series of genetic alterations and epigenetic changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1(SIRT1), an NAD+-dependent protein deacetylase, is capable of deacetylating histones and non-histone substrates that regulate various physiological activities during tumorigenesis.
Liz M, Garcia-Peterson, Xiaoling, Li
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Journal of Biological Standardization, 1984
One of the current criteria for evaluating the acceptability of cell lines for use in vaccine production is lack of tumorigenicity. Vero cells represent an example of a class of cells known as continuous cell lines. They were derived from African green monkey kidney, and their growth properties and culture characteristics have many advantages over ...
I S, Levenbook +2 more
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One of the current criteria for evaluating the acceptability of cell lines for use in vaccine production is lack of tumorigenicity. Vero cells represent an example of a class of cells known as continuous cell lines. They were derived from African green monkey kidney, and their growth properties and culture characteristics have many advantages over ...
I S, Levenbook +2 more
openaire +2 more sources