Results 101 to 110 of about 66,124 (248)

Supplementary materials and methods, Supplementary Table 1, and Supplementary Figure Legends from MIF Maintains the Tumorigenic Capacity of Brain Tumor–Initiating Cells by Directly Inhibiting p53

, 2023
Raita Fukaya, Shigeki Ohta, Tomonori Yaguchi, Yumi Matsuzaki, Eiji Sugihara, Hideyuki Okano, Hideyuki Saya, Yutaka Kawakami, Takeshi Kawase, Kazunari Yoshida, Masahiro Toda   +10 more
openalex   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

The Human Soluble NKG2D Ligand Differentially Impacts Tumorigenicity and Progression in Temporal and Model-Dependent Modes

Biomedicines
NKG2D is an activating receptor expressed by all human NK cells and CD8 T cells. Harnessing the NKG2D/NKG2D ligand axis has emerged as a viable avenue for cancer immunotherapy.
Anthony V. Serritella, Pablo Saenz-Lopez Larrocha, Payal Dhar, Sizhe Liu, Milan M. Medd, Shengxian Jia, Qi Cao, Jennifer D. Wu   +7 more
doaj   +1 more source

Supplementary Figure 1 from Acyl-CoA Synthetase VL3 Knockdown Inhibits Human Glioma Cell Proliferation and Tumorigenicity

, 2023
Zhengtong Pei, Peng Sun, Ping Huang, Bachchu Lal, John Laterra, Paul A. Watkins   +5 more
openalex   +1 more source

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source

Mitochondrial genetics – New model uncovering roles in tumorigenicity and metastasis

, 2018
Thomas C. Beadnell, Danny R. Welch
openalex   +1 more source

Supplementary Figure S2 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation

, 2023
Saurabh Agarwal, Anna Lakoma, Zaowen Chen, John Hicks, Leonid S. Metelitsa, Eugene S. Kim, Jason M. Shohet   +6 more
openalex   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells

Cell Reports Medicine
Summary: Glioblastoma (GBM) stem cells (GSCs) contribute to poor prognosis in patients with GBM. Identifying molecular markers is crucial for developing targeted therapies.
Shuchang Zhou, Weiwei Lin, Xiong Jin, Rui Niu, Zheng Yuan, Tianran Chai, Qi Zhang, Meixia Guo, Sung Soo Kim, Meichen Liu, Yilin Deng, Jong Bae Park, Sun Il Choi, Bingyang Shi, Jinlong Yin   +14 more
doaj   +1 more source

Supplemental Materials and Methods from Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth

, 2023
Rajneesh Pathania, Sabarish Ramachandran, G. Mariappan, Priyanka Thakur, Huidong Shi, Jeong-Hyeon Choi, Santhakumar Manicassamy, Ravindra Kolhe, Puttur D. Prasad, Suash Sharma, Bal L. Lokeshwar, Vadivel Ganapathy, Muthusamy Thangaraju   +12 more
openalex   +1 more source