Results 251 to 260 of about 155,806 (387)

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Efficacy and safety of intrathecal human umbilical cord-derived mesenchymal stromal cell therapy for bone cancer pain: a preclinical study. [PDF]

Stem Cell Res Ther
Zhang J, Li Y, Ren P, Jiang M, Wu P, Wen Q.   +5 more
europepmc   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

[Retracted] Inhibition of EMMPRIN by microRNA-124 suppresses the growth, invasion and tumorigenicity of gliomas. [PDF]

Exp Ther Med
Song Y, Bai L, Yan F, Chen C.
europepmc   +1 more source

Clathrin switches transforming growth factor-β role to pro-tumorigenic in liver cancer [PDF]

, 2019
Daniel Caballero‐Díaz, Esther Bertrán, Irene Peñuelas‐Haro, Joaquim Moreno‐Càceres, Andrea Malfettone, Judit López‐Luque, Annalisa Addante, Blanca Herrera, Aranzazu Sánchez, Ania Alay, Xavier Solé, Teresa Serrano, Emilio Ramos, Isabel Fabregat   +13 more
openalex   +1 more source

Additional file 8 of Neural stemness contributes to cell tumorigenicity

, 2021
Liyang Xu, Min Zhang, Lihua Shi, Xiaoli Yang, Lu Chen, Ning Cao, Anhua Lei, Ying Cao   +7 more
openalex   +1 more source

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

Cell, 2013
Christine L. Chaffer, N. Marjanovic, T. Lee, G. Bell, C. Kleer, Ferenc Reinhardt, A. D’Alessio, R. Young, R. Weinberg   +8 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Extruded nanovesicles derived from umbilical cord mesenchymal stem cells exhibit No tumorigenic potential. [PDF]

Bioact Mater
Wang F, Li L, Deng J, Mo S, Ai J, Xiao Y, Li Q, Ding D, Zhang Y, Zhou D, Li Z.   +10 more
europepmc   +1 more source

Image 3_Immune intrinsic escape signature stratifies prognosis, characterizes the tumor immune microenvironment, and identifies tumorigenic PPP1R8 in glioblastoma multiforme patients.tif

Ran Du (552530), Lijun Jing (573565), Denggang Fu (5082062)   +2 more
openalex   +1 more source