Results 261 to 270 of about 155,806 (387)

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

sST2 as a Promising Cardiac Biomarker After Ischemic Stroke With Elevated Systolic Blood Pressure. [PDF]

JACC Asia
Tu Y, Wang M, Wu S, Jiang H, Long J, Peng Y, Zhang Y, Xu T, Xiao G, Zhong C.   +9 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Optimization of Culture Media for Human Umbilical Cord-Derived Mesenchymal Stem Cell Production. [PDF]

Stem Cells Int
Chu W, Liu M, Shangguan Y, He F, Zeng X, Guo T, Li T, Zhang F, Wang Q, Wu J, Zhong Z, Liang X.   +11 more
europepmc   +1 more source

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence‐related genes [PDF]

, 2012
Hironori Iwasaki, Kenji Nakano, Kentaro Shinkai, Yumi Kunisawa, Minako Hirahashi, Yoshinao Oda, Hideya Onishi, Mitsuo Katano   +7 more
openalex   +1 more source

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.

Cancer Cell, 2013
Eunhee Kim, Mi-Suk Kim, Dong-Hun Woo, Y. Shin, Jihye Shin, Nakho Chang, Young-Taek Oh, Hong‐Gyum Kim, Jingeun Rheey, I. Nakano, Cheolju Lee, K. Joo, J. Rich, D. Nam, Jeongwu Lee   +14 more
semanticscholar   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source

Safety Assessment of Stem Cell-Based Therapies: Current Standards and Advancing Frameworks. [PDF]

Cells
Leonov GE, Grinchevskaya LR, Makhnach OV, Samburova MV, Goldshtein DV, Salikhova DI.   +5 more
europepmc   +1 more source

Characterization of an Inducible Alcoholic Liver Fibrosis Model for Hepatocellular Carcinoma Investigation in a Transgenic Porcine Tumorigenic Platform

, 2018
Ron C. Gaba, Nasya Mendoza-Elias, Daniel P. Regan, Kelly García, R. Peter Lokken, Regina M. Schwind, Michael Eichner, Faith M. Thomas, Laurie A. Rund, Lawrence B. Schook, Kyle M. Schachtschneider   +10 more
openalex   +2 more sources

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma [PDF]

, 2013
Xin Xie, Longzhen Piao, Brooke N. Bullock, Ashley Smith, Tong Su, Ming Zhang, Theodoros N. Teknos, Paramjit S. Arora, Quintin Pan   +8 more
openalex   +1 more source