Results 271 to 280 of about 155,806 (387)

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Hsa_circ_0003611 hinders the transformation of mesenchymal stem cells into osteosarcoma cells through suppressing MYC by IGF2BP3 via m⁶A modification. [PDF]

Biol Res
Zhang F, Cheng F, He Z, Zhao C.
europepmc   +1 more source

Long-term stable expression of antisense cDNA of cyclin B1 profoundly inhibits the proliferation of tumor cells and suppresses tumorigenicity in implanted mice

, 2008
Tao Zhang, Ling Zhang, Ji‐Cheng Li, Wei Dong, Yuquan Wei, Ru Zhang, Cheng Peng, Xiancheng Chen, Huanyi Liu, Xiaomei Su   +9 more
openalex   +1 more source

Intratumoral Fusobacterium nucleatum Drives Cancer‐Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Fusobacterium nucleatum contributes to the progression of ESCC by inducing NF‐κB–mediated inflammatory signaling in tumor cells and promoting CAFs activation. Its presence may facilitate immune exclusion and tumor invasion through stromal remodeling. Furthermore, F.
Takashi Ofuchi, Qingjiang Hu, Kazuki Omachi, Kosuke Kanemitsu, Hajime Otsu, Yusuke Yonemura, Taro Tobo, Yoshifumi Baba, Masaaki Iwatsuki, Koshi Mimori   +9 more
wiley   +1 more source

Preclinical biodistribution and safety evaluation of human iPSC-derived dopaminergic neural progenitor cells for Parkinson's disease. [PDF]

Front Cell Dev Biol
Huang Y, Wen H, Li L, Li L, Li Q, Qin C, Mao Y, Lin Z, Jiang H, Zhu F, Li X, Geng X.   +11 more
europepmc   +1 more source

ASBEL–TCF3 complex is required for the tumorigenicity of colorectal cancer cells

Proceedings of the National Academy of Sciences of the United States of America, 2016
Kenzui Taniue, Akiko Kurimoto, Yasuko Takeda, T. Nagashima, M. Okada‐Hatakeyama, Y. Katou, K. Shirahige, T. Akiyama   +7 more
semanticscholar   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Analysing the effect of full-length and C-terminally truncated progranulin on proliferation, colony formation, and migration in HepG2 and U87 cells. [PDF]

Sci Rep
Hofer AM, Tobler L, Ruepp MD, Mühlemann O.   +3 more
europepmc   +1 more source

Tumorigenic effect of testosterone

The Lancet, 1990
Morris Pollard, E. Nieschlag, G.M.H. Waites, C.A. Paulsen, D.J. Handelsman   +4 more
openaire   +1 more source

HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity

Current Biology, 2007
V. Clément, P. Sánchez, N. Tribolet, I. Radovanovic, A. R. I. Altaba   +4 more
semanticscholar   +1 more source