Results 341 to 350 of about 155,806 (387)
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Journal of Biological Standardization, 1984
One of the current criteria for evaluating the acceptability of cell lines for use in vaccine production is lack of tumorigenicity. Vero cells represent an example of a class of cells known as continuous cell lines. They were derived from African green monkey kidney, and their growth properties and culture characteristics have many advantages over ...
I S, Levenbook +2 more
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One of the current criteria for evaluating the acceptability of cell lines for use in vaccine production is lack of tumorigenicity. Vero cells represent an example of a class of cells known as continuous cell lines. They were derived from African green monkey kidney, and their growth properties and culture characteristics have many advantages over ...
I S, Levenbook +2 more
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Saccharin Metabolism and Tumorigenicity
Science, 1979Exposure of male Charles River CD1 rats to a 5 percent saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (< 0.4 percent of the oral dose) of tritiated saccharin in vivo.
T W, Sweatman, A G, Renwick
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International Journal of Gynecology & Obstetrics, 1979
This report presents a review of tumors, except those of pituitary, that have been reported to occur in women taking combined oral contraceptive preparations. Pathologic features, both gross and microscopic, and differential diagnosis are emphasized. Particular attention is given to tumors of the liver: focal nodular hyperplasia (hepatic hamartoma) and
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This report presents a review of tumors, except those of pituitary, that have been reported to occur in women taking combined oral contraceptive preparations. Pathologic features, both gross and microscopic, and differential diagnosis are emphasized. Particular attention is given to tumors of the liver: focal nodular hyperplasia (hepatic hamartoma) and
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Actin synthesis in tumorigenic and non-tumorigenic human hybrid cells
Journal of Cell Science, 1985ABSTRACT We have previously shown that the total actin content of tumorigenic HeLa/fibroblast somatic cell hybrids is significantly lower than that of the non-tumorigenic hybrid cells. A measure of actin synthesis, relative to total protein synthesis, was obtained for these cells to determine whether the reduced actin content of the ...
L R, Gowing, R L, Tellam, M R, Banyard
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An Index of Tumorigenic Potency
Biometrics, 1993A new index of tumorigenic potency is derived using a survival-adjusted quantal response estimator given by Bailer and Portier (1988, Biometrics 44, 417-431). The small-sample bias and mean squared error properties of this estimator are explored using computer simulations of animal carcinogenicity experiments and are compared to the characteristics of ...
Bailer, A. John, Portier, Christopher J.
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STEM CELLS, 1994
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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Pluripotency and tumorigenicity
Nature Genetics, 2002Pluripotent stem cells are essential for embryonic development and regeneration of adult tissues. But when the molecular pathways that control stem cells go awry, the result can often be the development of tumors. Wnt signaling mediated by the intracellular transducer β-catenin and the tumor suppressor APC (adenomatosis polyposis coli) is pivotal in ...
Joshua M. Brickman, Thomas G. Burdon
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Homogeneously staining regions and tumorigenicity
International Journal of Cancer, 1983AbstractA homogeneously staining region (HSR), a chromosome abnormality associated with gene amplification, was found to increase in length coincident with an enhancement in tumorigenicity when cells from a human retinoblastoma cell line were serially passaged in athymic (nu/nu) mice.
F, Gilbert +4 more
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Pro-tumorigenic AMPK in glioblastoma
Nature Cell Biology, 2018AMPK is a key metabolic sensor promoting cellular energy homeostasis under low-nutrient conditions and other stresses. However, its role in cancer is context-dependent and not fully understood. A study now shows that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.
Nektaria Maria, Leli +1 more
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Suppression of tumorigenicity in cybrids
Journal of Supramolecular Structure and Cellular Biochemistry, 1981AbstractWe investigated cytoplasmic control of tumorigenicity in cybrids. Cytoplasts derived from nontumorigenic cells were fused to the highly tumorigenic 984 Cl 10–15 cell line derived from a murine teratoma. The resultant cybrids did not retain the tumorigenicity of the original cell line.
J W, Shay, G, Lorkowski, M A, Clark
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