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Linking Endocytosis and Tumorigenicity
Science Signaling, 2011Activation of receptor tyrosine kinases may not be enough for oncogenesis; excess signaling from endosomes may also be required.
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Regulating ROS for Tumorigenicity
Science Signaling, 2011Oncogenes can activate a reactive oxygen species-detoxification program to promote tumorigenesis.
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AAV vectors and tumorigenicity
Nature Biotechnology, 2007Chromosomal integration of rAAV vectors may induce hepatocellular carcinoma in neonatally treated mice.
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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Nature Cell Biology, 2009U. Wellner +19 more
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Genetics of Retrovirus Tumorigenicity
1986Retroviruses are the causative agents of a wide variety of malignant and degenerative diseases under natural and experimental conditions. These viruses may be oncogenic, whether or not they contain a viral oncogene. However, the presence of a viral oncogene alters and enhances their tumorigenicity.
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