Results 161 to 170 of about 1,569,619 (249)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Outcomes of Pediatric Neurosurgical Cases Managed by General Neurosurgeons: A Retrospective Study from Eastern India

Indian Journal of Neurosurgery
Abhijit Acharya, Satya Bhusan Senapati, Sumirini Puppala, AK Mahapatra   +3 more
doaj   +1 more source

Effect of <i>MYCN</i> Amplification on Tumor Response and Recurrence in Patients With Stage IV Neuroblastoma. [PDF]

JCO Precis Oncol
Matser YAH, van Kuilenburg ABP, Samim A, van Liempt LM, van Grotel M, Kraal KCJM, Dierselhuis MP, van Eijkelenburg NKA, Langenberg KPS, van Noesel MM, Molenaar J, Fiocco M, Tytgat GAM.   +12 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer. [PDF]

Commun Med (Lond)
Davies HR, Black D, Kvist A, Sigurjónsdóttir K, Bosch A, Bowden R, Memari Y, Chen Z, Rinaldi G, Rosengren F, Nacer DF, Veerla S, Hohmann L, Nordborg N, Häkkinen J, Vallon-Christersson J, Borg Å, Nik-Zainal S, Staaf J.   +18 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Special Issue: The Evolving Landscape of Single-Cell Genomics in CNS and PNS Oncology. [PDF]

Neurooncol Adv
Ellenbogen Y, Suva ML, Tirosh I.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling. [PDF]

J Immunother Cancer
Roulstone V, Kyula J, Appleton E, Bommareddy PK, Patrikeev A, Jones S, Kuncheria L, Chan Wah Hak CM, Foo S, Baldock H, Wongariyapak A, Leslie I, Pickering R, Zierhut C, Smith HG, Mohan N, Murano C, Hubbard LC, Dean I, Patin EC, Gkantalis J, Mansfield D, Pedersen M, McLaughlin M, Goicoechea M, Layzell S, Mannion J, Fernando W, Meier P, Vile R, Melcher A, Coffin RS, Harrington KJ.   +32 more
europepmc   +1 more source