Results 171 to 180 of about 2,238,052 (265)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

IgM promotes antitumor immunity to a Tn-expressing solid tumor. [PDF]

J Immunother Cancer
Nzuki HL, Jennings-Gee JE, Trivette M, Mosher TH, Adams-Sims AE, Hegarty AA, Haas KM.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Single-Cell Transcriptomics Reveals Biomarkers for NK Cell Dysfunction in Endometriosis-Associated Immune Dysregulation

Mediators of Inflammation
Wangshu Li, Kexin Zhu, Bowen Xu, Juan Nie, Fang Wang, Aziz ur Rehman Aziz, Xiaohui Yu, Daqing Wang, Chunfang Ha   +8 more
doaj   +1 more source

Contemporary Profile of Hybrid Nerve Sheath Tumors: Clinical, Anatomical, and Imaging Characteristics. [PDF]

Cancers (Basel)
Grübel N, Uerschels AK, Gembruch O, Wrede K, Schöffing F, Hohenhaus M, Scholz C, Hobitsch K, Kretschmer T, D'Souza S, Dengler NF, Wirtz CR, Deininger S, Osterloh A, Bremer J, Pedro MT, On Behalf Of The Peripheral Nerve Tumor Study Pntr Study Group.   +16 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Prevalence and clinical relevance of negative histology after transsphenoidal surgery for pituitary neuroendocrine tumors. [PDF]

Front Endocrinol (Lausanne)
De Cannière G, Raftopoulos C, Maiter D, de Nijs L, Daoud L, Constantinescu SM, Alexopoulou O, Fomekong E.   +7 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The epidemiological landscape of canine tumors in central Italy: animal cancer registry insights, distribution patterns, and incidence estimates. [PDF]

Front Vet Sci
Carnio A, Cocumelli C, Galietta V, Fonti N, Simeoni S, Barberini M, Panetta V, Scaramozzino P, Millanta F, Eleni C, Carvelli A.   +10 more
europepmc   +1 more source