Results 161 to 170 of about 2,238,052 (265)

Malignant Melanoma Bone Metastasis With Unknown Primary Site: A Case Report and Literature Review

Case Reports in Orthopedics
Cao Wang, Yan Liu, Lei Han, Xin Qu, Hang Yang, Fengming Ran, Dongqi Li, Dachang Xu, Chenying Yang, Zuozhang Yang   +9 more
doaj   +1 more source

The Impact of SF3B1 Mutations on the Tumor Microenvironment and Response to Immunotherapy. [PDF]

Cancer Med
Cho KJ, Lim B.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Young Aggressive Prostate Tumors Exhibit Increased Genomic Instability and an Exploratory RNA-CNA-Concordant Transcriptomic Pattern. [PDF]

Int J Mol Sci
Bergez-Hernández F, Martínez-Camberos A, Romero-Quintana G, Parra-Unda J, Garrido-Palazuelos L, Irigoyen Arredondo M.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Quantitative stability of MGMT promoter methylation in recurrent glioma and implications for temozolomide rechallenge. [PDF]

J Neurooncol
Noren H, Pelofsky G, Suffren B, Mittelman L, Yohn C, Twyman A, Febres-Aldana CA, Abramyan A, Sertil A, D'Amico RS, Sherman JH, Vojnic M.   +11 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The dual immune landscape of homologous recombination-deficient tumors: mechanisms and therapeutic implications. [PDF]

Cancer Metastasis Rev
Yang Y, Yin Y, Rong S, Qian Y, Li D, Zhang Y, Wang X.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

TFAP2B and FOXC1 are associated with biologically and clinically distinct differentiation states in triple-negative breast cancer. [PDF]

Sci Rep
Klaus FL, Kitzke I, Klein E, Kiechle M, Mogler C, Muckenhuber A.   +5 more
europepmc   +1 more source