Results 81 to 90 of about 3,330,839 (370)

Automatic Brain Tumor Segmentation using Cascaded Anisotropic Convolutional Neural Networks [PDF]

, 2017
A cascade of fully convolutional neural networks is proposed to segment multi-modal Magnetic Resonance (MR) images with brain tumor into background and three hierarchical regions: whole tumor, tumor core and enhancing tumor core. The cascade is designed to decompose the multi-class segmentation problem into a sequence of three binary segmentation ...
arxiv   +1 more source

Statistical mechanics model of angiogenic tumor growth [PDF]

Phys.Rev. E 85, 010901(R) (2012), 2011
We examine a lattice model of tumor growth where survival of tumor cells depends on the supplied nutrients. When such a supply is random, the extinction of tumors belongs to the directed percolation universality class. However, when the supply is correlated with distribution of tumor cells, which as we suggest might mimick the angiogenic growth, the ...
arxiv   +1 more source

MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance

Advanced Science
O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ).
Junfeng Xu, Xin Lou, Fei Wang, Wuhu Zhang, Xiaowu Xu, Zeng Ye, Qifeng Zhuo, Yan Wang, Desheng Jing, Guixiong Fan, Xuemin Chen, Yue Zhang, Chenjie Zhou, Jie Chen, Yi Qin, Xianjun Yu, Shunrong Ji   +16 more
doaj   +1 more source

Natural Killer cells in non-hematopoietic malignancies

Frontiers in Immunology, 2012
Natural killer (NK) cells belong to the innate immune system and were initially described functionallywise by their spontaneous cytotoxic potential against transformed or virus-infected cells.
Mélanie eDesbois, Sylvie eRusakiewicz, Clara eLocher, laurence eZitvogel, Nathalie eChaput   +4 more
doaj   +1 more source

Breast Cancer Automatic Diagnosis System using Faster Regional Convolutional Neural Networks [PDF]

, 2019
Breast cancer is one of the most frequent causes of mortality in women. For the early detection of breast cancer, the mammography is used as the most efficient technique to identify abnormalities such as tumors.
Amaya Rodríguez, Isabel, Civit Masot, Javier, Domínguez Morales, Juan Pedro, Durán López, Lourdes, Linares Barranco, Alejandro, Luna Perejón, Francisco, Vicente Díaz, Saturnino   +6 more
core   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation [PDF]

, 2016
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors.
Aldo Scarpa, Aust, Daniela, Bailey, Peter, Bellair, Michelle, Biankin, Andrew V, Chang, David K, Claudio Bassi, Covington, Kyle R, Creighton, Chad J, Dahdouli, Mike, Dewal, Ninad, Dinh, Huyen H, Doddapaneni, Harsha, Donehower, Lawrence A, Drummond, Jennifer, Duthie, Fraser R, Fisher, William E, Gibbs, Richard A, Gill, Anthony J, Gingras, Marie-Claude, Grimmond, Sean M, Grützmann, Robert, Hampton, Oliver A, Han, Yi, Harliwong, Ivon, Hodges, Sally E, Hruban, Ralph H, Hu, Jianhong, Ittmann, Michael M, Jamieson, Nigel B, Johns, Amber L, Lee, Sandra L, Maria Scardoni, McElhany, Amy, Muzny, Donna M, Oien, Karin A, Overman, Michael J, Pearson, John V, Pilarsky, Christian, Rita T. Lawlor, Saengboonmee, Charupong, Samra, Jaswinder S, Shinbrot, Eve, Stefania Beghelli, Van Buren, George, Vincenzo Corbo, Waddell, Nicola, Walker, Kimberly, Wang, Huamin, Wheeler, David A, Xi, Liu   +50 more
core   +3 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Metastasis to parotid gland from non Head and Neck tumors [PDF]

, 2018
Most primary tumors spreading metastasis to the parotid gland are usually located in the head and neck region, nonetheless, rarely, parotid gland can also be the target of metastatic localization site of distant primary tumors.
Andrea, Ciorba, Bianchini, Chiara, Borsetto, Daniele, Cazzador, Diego, Enzo, Emanuelli, Francesco, Stomeo, Fusetti, Stefano, Marino, Filippo, Sarcognato, Samantha, Stefano, Pelucchi   +9 more
core  

Accuracy of computerized tomography in determining hepatic tumor size in patients receiving liver transplantation or resection [PDF]

, 1984
Computerized tomography (CT) of liver is used in oncologic practice for staging tumors, evaluating response to treatment, and screening patients for hepatic resection.
Bron, K, Dekker, A, Iwatsuki, S, Kowal, C, Mittal, R, Schade, R, Starzl, T, Straub, W, Van Thiel, D   +8 more
core   +1 more source