Results 81 to 90 of about 5,905,711 (364)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

VENTRAL SPONDYLODESIS BYTITAN IMPLANTS AT SPINE TUMORS

Travmatologiâ i Ortopediâ Rossii, 2016
At RSPC of traumatology and orthopaedic surgery and Institute of powders metallurgic porous implants are working out which allow complitely replace alio- and autotranplants and improve the surgical technology of interbody spondylodesis.
A. V. Babkin
doaj   +1 more source

Dermoscopy of Cutaneous Neoplasms in Skin of Color – A Systematic Review by the International Dermoscopy Society “Imaging in Skin of Color” Task Force

Dermatology Practical & Conceptual, 2023
Over the last few decades, dermoscopy has been showed to facilitate the non-invasive diagnosis of both benign and malignant skin tumors, yet literature data mainly comes from studies on light phototypes.
Nkechi Anne Enechukwu, Biswanath Behera, Delaney D Ding, Aimilios Lallas, Payal Chauhan, Soumil Khare, Martyna Sławińska, Bengu Nisa Akay, Balachandra S Ankad, Yasmeen J Bhat, Abhijeet Kumar Jha, Feroze Kaliyadan, Awatef Kelati, Shekhar Neema, Nisha V Parmar, Jennifer Stein, Richard P Usatine, Keshavamurthy Vinay, Adebola Olufunmilayo Ogunbiyi, Enzo Errichetti   +19 more
doaj   +1 more source

An endotoxin-induced serum factor that causes necrosis of tumors.

Proceedings of the National Academy of Sciences of the United States of America, 1975
In studying "hemorrhagic necrosis" of tumors produced by endotoxin, it was found that the serum of bacillus Calmette--Guerin (BCG)-infected mice treated with endotoxin contains a substance (tumor necrosis factor; TNF) which mimics the tumor necrotic ...
E. Carswell, L. Old, R. Kassel, S. Green, N. Fiore, B. Williamson   +5 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study

Frontiers in Immunology, 2022
BackgroundCentral nervous system tumor (CNST) is one of the most complicated and lethal forms of human tumors with very limited treatment options. In recent years, growing evidence indicates that oncolytic virotherapy (OVT) has emerged as a promising ...
Kunming Cheng, Huan Zhang, Qiang Guo, Qiang Guo, Pengfei Zhai, Pengfei Zhai, Yan Zhou, Yan Zhou, Yan Zhou, Weiguang Yang, Weiguang Yang, Yulin Wang, Yulin Wang, Yanqiu Lu, Zefeng Shen, Haiyang Wu, Haiyang Wu   +16 more
doaj   +1 more source

Breast Cancer Automatic Diagnosis System using Faster Regional Convolutional Neural Networks [PDF]

, 2019
Breast cancer is one of the most frequent causes of mortality in women. For the early detection of breast cancer, the mammography is used as the most efficient technique to identify abnormalities such as tumors.
Amaya Rodríguez, Isabel, Civit Masot, Javier, Domínguez Morales, Juan Pedro, Durán López, Lourdes, Linares Barranco, Alejandro, Luna Perejón, Francisco, Vicente Díaz, Saturnino   +6 more
core   +1 more source

Glomangiomyoma of the knee : a rare juxtasynovial presentation [PDF]

, 2020
Glomus tumors are benign tumors typically located in the subcutis or deep dermis of the subungual region of the fingers. Histologically, glomus tumors are divided into three subtypes, in descending order of frequency: solid glomus tumor, glomangioma and ...
De Backer, Adelard, Hustings, Nico, Vanhoenacker, Filip   +2 more
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance

Advanced Science
O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ).
Junfeng Xu, Xin Lou, Fei Wang, Wuhu Zhang, Xiaowu Xu, Zeng Ye, Qifeng Zhuo, Yan Wang, Desheng Jing, Guixiong Fan, Xuemin Chen, Yue Zhang, Chenjie Zhou, Jie Chen, Yi Qin, Xianjun Yu, Shunrong Ji   +16 more
doaj   +1 more source