Results 1 to 10 of about 752,560 (269)

Sensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours

npj Genomic Medicine, 2022
Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity, have disparate prognoses depending on their origin.
Geoffrey J. Maher, Rosemary A. Fisher, Baljeet Kaur, Xianne Aguiar, Preetha Aravind, Natashia Cedeno, James Clark, Debbie Damon, Ehsan Ghorani, Adam Januszewski, Foteini Kalofonou, Ravindhi Murphy, Rajat Roy, Naveed Sarwar, Mark R. Openshaw, Michael J. Seckl   +15 more
doaj   +1 more source

Synovial fluid pH is as specific as synovial leukocyte count but less sensitive for the diagnosis of chronic prosthetic joint infection

Journal of Orthopaedics and Traumatology, 2022
Background Synovial fluid markers (synovial leukocyte count and differential) have been shown to be most accurate in diagnosing prosthetic joint infection (PJI).
Christoph Theil, Thomas Ackmann, Georg Gosheger, Jan Puetzler, Burkhard Moellenbeck, Jan Schwarze, Martin Schulze, Sebastian Klingebiel   +7 more
doaj   +1 more source

Human papillomavirus E6 and E7: What remains?

Tumour Virus Research, 2021
Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us huge amounts of data on their expression, functions and structures.
Arushi Vats, Oscar Trejo-Cerro, Miranda Thomas, Lawrence Banks   +3 more
doaj   +1 more source

Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging

Nanoscale Research Letters, 2020
Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR
Zhenhui Nie, Ningbin Luo, Junjie Liu, Xinyi Zeng, Yu Zhang, Danke Su   +5 more
doaj   +1 more source

A single centre study of 41 cases on the use of porous tantalum metal implants in acetabular revision surgery

BMC Musculoskeletal Disorders, 2019
Background This study aims at investigating cup survival of porous tantalum revision cups and identifies risk factors for failure. Methods We retrospectively reviewed 41 patients treated between 2010 and 2012.
Christoph Theil, Tom Schmidt-Braekling, Georg Gosheger, Burkhard Moellenbeck, Jan Schwarze, Ralf Dieckmann   +5 more
doaj   +1 more source

Emerging role of m6A methylation modification in ovarian cancer

Cancer Cell International, 2021
m6A (N6-methyladenosine) methylation, a well-known modification in tumour epigenetics, dynamically and reversibly fine tunes the entire process of RNA metabolism.
Lin-Lin Chang, Xia-Qing Xu, Xue-Ling Liu, Qian-Qian Guo, Yan-Nan Fan, Bao-Xia He, Wen-Zhou Zhang   +6 more
doaj   +1 more source

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression

npj Breast Cancer, 2023
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease.
Shayin V. Gibson, Elena Tomas Bort, Lucía Rodríguez-Fernández, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Ulrich auf dem Keller, Andrea Agnoletto, Cathrin Brisken, Barrie Peck, Angus J. Cameron, John F. Marshall, J. Louise Jones, Edward P. Carter, Richard P. Grose   +14 more
doaj   +1 more source

Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6

Journal of Experimental & Clinical Cancer Research, 2019
Background Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC).
Li Jiang, Xu-Hai Zhao, Yin-Ling Mao, Jun-Feng Wang, Hui-Jun Zheng, Qing-Shan You   +5 more
doaj   +1 more source

EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes

Nature Communications, 2017
InDrosophila, ecdysone-regulated genes are bound by a heterodimer of ecdysone receptor (EcR) and Ultraspiracle. Here, the authors provide evidence of a non-canonical complex containing EcR and the nucleosome remodeller dMi-2 that limits transcription of ...
Judith Kreher, Kristina Kovač, Karim Bouazoune, Igor Mačinković, Anna Luise Ernst, Erik Engelen, Roman Pahl, Florian Finkernagel, Magdalena Murawska, Ikram Ullah, Alexander Brehm   +10 more
doaj   +1 more source