Results 91 to 100 of about 1,360,599 (360)

Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment

Nature Communications
With the success of immunotherapy in cancer, understanding the tumor immune microenvironment (TIME) has become increasingly important; however in pediatric brain tumors this remains poorly characterized.
Adrian B. Levine, Liana Nobre, Anirban Das, Scott Milos, Vanessa Bianchi, Monique Johnson, Nicholas R. Fernandez, Lucie Stengs, Scott Ryall, Michelle Ku, Mansuba Rana, Benjamin Laxer, Javal Sheth, Stefanie-Grace Sbergio, Ivana Fedoráková, Vijay Ramaswamy, Julie Bennett, Robert Siddaway, Uri Tabori, Cynthia Hawkins   +19 more
doaj   +1 more source

Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

Nature Communications, 2018
ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2.
Kristina Kovač, Anja Sauer, Igor Mačinković, Stephan Awe, Florian Finkernagel, Helen Hoffmeister, Andreas Fuchs, Rolf Müller, Christina Rathke, Gernot Längst, Alexander Brehm   +10 more
doaj   +1 more source

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

Nature Communications, 2020
Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.
S. Di Blasio, G. F. van Wigcheren, A. Becker, A. van Duffelen, M. Gorris, K. Verrijp, I. Stefanini, G. J. Bakker, M. Bloemendal, A. Halilovic, A. Vasaturo, G. Bakdash, S. V. Hato, J. H. W. de Wilt, J. Schalkwijk, I. J. M. de Vries, J. C. Textor, E. H. van den Bogaard, M. Tazzari, C. G. Figdor   +19 more
doaj   +1 more source

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. [PDF]

, 2016
Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which
Backofen, Rolf, Cao, Xuhong, Chinnaiyan, Arul M, Collins, Colin, Feng, Felix Y, Gawronski, Alexander, Han, Sumin, Hayes, Daniel F, Hosono, Yasuyuki, Iyer, Matthew K, Kregel, Steven, Ma, Teng, Malik, Rohit, Niknafs, Yashar S, Pierce, Lori J, Pitchiaya, Sethuramasundaram, Poliakov, Anton, Prensner, John R, Rae, James M, Sahinalp, Cenk S, Siebenaler, Ronald F, Singhal, Udit, Speers, Corey, Uhl, Michael, Wilder-Romans, Kari, Xiao, Lanbo, Zhang, Chao, Zhao, Shuang G   +27 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Coprevalence of modifiable gastric cancer risk factors and gastric health among Chinese high-risk groups

Scientific Reports
This study aims to characterise the distribution and co-prevalence patterns of 11 modifiable gastric cancer (GC) risk factors and to examine their association with gastric health. The research utilised baseline data from the upper gastrointestinal cancer
Xiang Feng, Jinhua Zhu, Chun Dai, Zhaolai Hua, Jiashan Zhu   +4 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The deubiquitylating enzyme Fat facets promotes Fat signalling and restricts tissue growth

Nature Communications
Tissue growth is regulated by many signals, including polarity cues. The Hippo signalling pathway restricts tissue growth and receives inputs from the planar cell polarity-controlling Fat signalling pathway. The atypical cadherin Fat restricts growth via
Lauren E. Dawson, Aashika Sekar, Alexander D. Fulford, Rachel I. Lambert, Hannah S. Burgess, Paulo S. Ribeiro   +5 more
doaj   +1 more source

The Tumour Bank at the Children’s Hospital at Westmead: An Australian Paediatric Cancer Biorepository

Open Journal of Bioresources, 2018
The Tumor Bank at The Children’s Hospital at Westmead was established in 1998 with the purpose of facilitating research into childhood malignancy through the active provision of well annotated, ethically collected tissue samples and providing a pathway ...
Li Zhou, Aysen Yuksel, Oksana Markovich, Natalie Gabrael, Daniel Catchpoole   +4 more
doaj   +1 more source

Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma. [PDF]

, 2017
Almost all genomic studies of breast cancer have focused on well-established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.
Abdalla, Mohamed, Abdalla, Moustafa, Arneson, Nona, Boutros, Paul C, Cawthorn, Thomas R, Done, Susan J, Easson, Alexandra M, Fox, Natalie S, Iakovlev, Vladimir, Kanwar, Nisha, Kwan, Jennifer Yin Yee, Lee, Jennifer PY, Leong, Wey L, McCready, David, Miller, Naomi A, Moreno, Juan, Nair, Ranju, Tran-Thanh, Danh, Wang, Dong-Yu, Warren, Keisha, Youngson, Bruce J   +20 more
core   +2 more sources