Results 11 to 20 of about 752,560 (269)
Optimized exosome isolation protocol for cell culture supernatant and human plasma [PDF]
Journal of Extracellular Vesicles, 2015 Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information elucidating the most efficient methods for obtaining high yields of pure exosomes, a subset of ...
Richard J. Lobb +6 more
doaj +1 more source
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
Nature Communications, 2020 Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse ...
Sanja Pajovic +15 more
doaj +1 more source
Delays and routes to diagnosis of neuroendocrine tumours
BMC Cancer, 2018 Background Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendocrine tumours and also the ...
Ron Basuroy +4 more
doaj +1 more source
Molecular analysis of Annexin expression in cancer
BMC Cancer, 2022 Background Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface ...
Tobias Hein +2 more
doaj +1 more source
Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS
Molecular Systems Biology, 2012 RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood.
Iwona Stelniec‐Klotz +8 more
doaj +1 more source
p53 downregulates the Fanconi anaemia DNA repair pathway
Nature Communications, 2016 P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita.
Sara Jaber +4 more
doaj +1 more source
Nature Communications, 2021 Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken ...
Luize G. Lima +11 more
doaj +1 more source
Antibiotic Elution Characteristics and Pharmacokinetics of Gentamicin and Vancomycin from a Mineral Antibiotic Carrier: An in vivo Evaluation of 32 Clinical Cases [PDF]
Journal of Bone and Joint Infection, 2018 Introduction: Locally implanted antibiotic-eluting carriers may be a valuable adjuvant to the management of prosthetic joint infections. Aim: to assess local and plasma antibiotic concentrations as well as cumulative antibiotic urine excretion associated
T. Colding-Rasmussen +3 more
doaj +1 more source
Network quantification of EGFR signaling unveils potential for targeted combination therapy
Molecular Systems Biology, 2013 The epidermal growth factor receptor (EGFR) signaling network is activated in most solid tumors, and small‐molecule drugs targeting this network are increasingly available. However, often only specific combinations of inhibitors are effective. Therefore,
Bertram Klinger +11 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source