Results 11 to 20 of about 1,360,599 (360)

A single centre study of 41 cases on the use of porous tantalum metal implants in acetabular revision surgery

BMC Musculoskeletal Disorders, 2019
Background This study aims at investigating cup survival of porous tantalum revision cups and identifies risk factors for failure. Methods We retrospectively reviewed 41 patients treated between 2010 and 2012.
Christoph Theil, Tom Schmidt-Braekling, Georg Gosheger, Burkhard Moellenbeck, Jan Schwarze, Ralf Dieckmann   +5 more
doaj   +1 more source

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

Emerging role of m6A methylation modification in ovarian cancer

Cancer Cell International, 2021
m6A (N6-methyladenosine) methylation, a well-known modification in tumour epigenetics, dynamically and reversibly fine tunes the entire process of RNA metabolism.
Lin-Lin Chang, Xia-Qing Xu, Xue-Ling Liu, Qian-Qian Guo, Yan-Nan Fan, Bao-Xia He, Wen-Zhou Zhang   +6 more
doaj   +1 more source

Characterising the tumour morphological response to therapeutic intervention:an ex vivo model [PDF]

, 2012
In cancer, morphological assessment of histological tissue samples is a fundamental part of both diagnosis and prognosis. Image analysis offers opportunities to support that assessment through quantitative metrics of morphology.
Bown, James L., Eberst, Alistair, Falconer, Ruth E., Harrison, David J., Houston, Alasdair N., Katz, Elad, Savage, Anne   +6 more
core   +5 more sources

Calcium signalling links MYC to NUAK1 [PDF]

, 2018
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,, Knight, J.R., Monteverde, T., Murphy, D.J., Sansom, O.J., Tait-Mulder, J.   +5 more
core   +1 more source

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Nature Communications, 2020
Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse ...
Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth, Patricia Rakopoulos, Byungjin Kim, Scott Ryall, Sameer Agnihotri, Lauren Phillips, Man Yu, Christopher Li, Scott Milos, Palak Patel, Dilakshan Srikanthan, Annie Huang, Cynthia Hawkins   +15 more
doaj   +1 more source

TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression

npj Breast Cancer, 2023
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease.
Shayin V. Gibson, Elena Tomas Bort, Lucía Rodríguez-Fernández, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Ulrich auf dem Keller, Andrea Agnoletto, Cathrin Brisken, Barrie Peck, Angus J. Cameron, John F. Marshall, J. Louise Jones, Edward P. Carter, Richard P. Grose   +14 more
doaj   +1 more source

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer [PDF]

, 2008
The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited.
A Ciucci, A Lannigan, A-M McNicol, AHS Lee, AHS Lee, AM Al Murri, AM Al Murri, AM Al Murri, AM McNicol, B Uzzan, C Badoual, C O'Sullivan, C Wilson, CD Griffith, CG Lis, D C McMillan, DC McMillan, DC McMillan, DC McMillan, EJ Bromwich, EY Lin, G Zhang, H Trihia, HM Ogmundsdottir, HO Wintzer, I Laursen, J Bell, J C Doughty, J Galon, J Vakkila, JA Anderson, JA Soreide, JL Yu, K Canna, KV Albuquerque, LM Coussens, LM Forrest, M Hilmy, M Retsky, M Toi, MC Haffner, MP Margarson, N Jonjic, P Goldwasser, P Reizenstein, PA McArdle, RD Leek, S Hansen, S Hansen, S Tsutsui, S Vgenopoulou, SM Pupa, SM Veronese, T Scholzen, TH Stewart, V Carstairs, Y Zhou   +56 more
core   +2 more sources

Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6

Journal of Experimental & Clinical Cancer Research, 2019
Background Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC).
Li Jiang, Xu-Hai Zhao, Yin-Ling Mao, Jun-Feng Wang, Hui-Jun Zheng, Qing-Shan You   +5 more
doaj   +1 more source

EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes

Nature Communications, 2017
InDrosophila, ecdysone-regulated genes are bound by a heterodimer of ecdysone receptor (EcR) and Ultraspiracle. Here, the authors provide evidence of a non-canonical complex containing EcR and the nucleosome remodeller dMi-2 that limits transcription of ...
Judith Kreher, Kristina Kovač, Karim Bouazoune, Igor Mačinković, Anna Luise Ernst, Erik Engelen, Roman Pahl, Florian Finkernagel, Magdalena Murawska, Ikram Ullah, Alexander Brehm   +10 more
doaj   +1 more source