Optimized exosome isolation protocol for cell culture supernatant and human plasma [PDF]
Journal of Extracellular Vesicles, 2015 Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information elucidating the most efficient methods for obtaining high yields of pure exosomes, a subset of ...
Richard J. Lobb +6 more
doaj +1 more source
Adaptive immunity in cancer immunology and therapeutics. [PDF]
, 2014 Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,
Lockley, M, Spurrell, EL
core +2 more sources
Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game [PDF]
, 2011 BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local ...
Alexander R. A. Anderson +5 more
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Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice [PDF]
, 2015 Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated.
BENIGNI, GIORGIA +13 more
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Molecular analysis of Annexin expression in cancer
BMC Cancer, 2022 Background Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface ...
Tobias Hein +2 more
doaj +1 more source
Malignant melanoma of the urethra: a rare histologic subdivision of vulvar cancer with a poor prognosis [PDF]
, 2012 Malignant melanoma of the urethra is a rare tumour that is difficult to diagnose and treat, resulting in a poor prognosis. In this paper, we present the case of a 65-year-old woman who was referred to a gynaecologist because of a urethral mass that ...
Alkatout, Ibrahim +8 more
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Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS
Molecular Systems Biology, 2012 RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood.
Iwona Stelniec‐Klotz +8 more
doaj +1 more source
MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. [PDF]
, 2008 The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients.
Hawinkels, LJAC +8 more
core +2 more sources
Delays and routes to diagnosis of neuroendocrine tumours
BMC Cancer, 2018 Background Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendocrine tumours and also the ...
Ron Basuroy +4 more
doaj +1 more source
Infrared laser pulse triggers increased singlet oxygen production in tumour cells [PDF]
, 2013 Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (1O2) generation via a laser excited photosensitiser (PS) to kill cancer cells.
Goltsov, Alexey +5 more
core +4 more sources