Results 31 to 40 of about 1,360,599 (360)

Network quantification of EGFR signaling unveils potential for targeted combination therapy

Molecular Systems Biology, 2013
The epidermal growth factor receptor (EGFR) signaling network is activated in most solid tumors, and small‐molecule drugs targeting this network are increasingly available. However, often only specific combinations of inhibitors are effective. Therefore,
Bertram Klinger, Anja Sieber, Raphaela Fritsche‐Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers, Nils Blüthgen   +11 more
doaj   +1 more source

Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: A randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine [PDF]

, 2018
Background: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80%
Chee, Raphael, Clay, Tim, Feeney, Kynan T, Galvao, Daniel A, Hart, Nicolas H, Martin, Hilary, Newton, Robert U, Redfern, Andrew D, Saunders, Christobel, Spry, Nigel A, Taaffe, Dennis R, Tsoi, Daphne   +11 more
core   +7 more sources

Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution

Nature Communications, 2021
Cancer derived exosomes are reported to promote metastatic dissemination. Here the authors show that cytokines in the tumor microenvironment bind to exosomes via glycosaminoglycan side chains of proteoglycans, and these exosomes are preferentially taken ...
Luize G. Lima, Sunyoung Ham, Hyunku Shin, Edna P. Z. Chai, Erica S. H. Lek, Richard J. Lobb, Alexandra F. Müller, Suresh Mathivanan, Belinda Yeo, Yeonho Choi, Belinda S. Parker, Andreas Möller   +11 more
doaj   +1 more source

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer. [PDF]

, 2015
The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour
Banerji, CR, Caldas, C, Severini, S, Teschendorff, AE   +3 more
core   +3 more sources

Antibiotic Elution Characteristics and Pharmacokinetics of Gentamicin and Vancomycin from a Mineral Antibiotic Carrier: An in vivo Evaluation of 32 Clinical Cases [PDF]

Journal of Bone and Joint Infection, 2018
Introduction: Locally implanted antibiotic-eluting carriers may be a valuable adjuvant to the management of prosthetic joint infections. Aim: to assess local and plasma antibiotic concentrations as well as cumulative antibiotic urine excretion associated
T. Colding-Rasmussen, P. Horstmann, M. M. Petersen, W. Hettwer   +3 more
doaj   +1 more source

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]

, 2008
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin, Batran, Salah-Eddin al-, Blaheta, Roman A., Hudak, Lukasz, Jonas, Dietger, Jüngel, Eva, Soldato, Piero Del, Sparatore, Anna, Wedel, Steffen Alexander   +8 more
core   +1 more source

p53 downregulates the Fanconi anaemia DNA repair pathway

Nature Communications, 2016
P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita.
Sara Jaber, Eléonore Toufektchan, Vincent Lejour, Boris Bardot, Franck Toledo   +4 more
doaj   +1 more source

Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications [PDF]

, 2009
Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid.
A Bertuzzi, A Bertuzzi, A Iordan, A Masi De, A Tosin, AC Newby, Andrea Tosin, BS Winters, CJW Breward, CJW Breward, CJW Breward, D Ambrosi, D Ambrosi, D Ambrosi, D Ambrosi, E Behravesh, E Canetta, G Forgacs, GA Truskey, H Oxlund, HM Byrne, HM Byrne, HP Greenspan, IJ Rao, JD Humphrey, JD Humphrey, JP Iredale, L Graziano, L Preziosi, LA Liotta, Luigi Preziosi, M Chaplain, M Sun, PA DiMilla, PA DiMilla, PP Pujuguet, PRA Johnson, RP Araujo, RP Araujo, RP Araujo, RP Araujo, S Astanin, SJ Franks, SJ Franks, SJ Franks, SP Palecek, V Lanza, W Baumgartner, WY Gu, YC Fung   +49 more
core   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Functional Role of miR-499a-5p in the Development of Gastric Cancer

The Turkish Journal of Gastroenterology
Background/Aims: Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC.
Cuiling Lu, Chengwang Guo, Cuihua Wu, Liping Zhang, Xiaoling Liu, Shoucun Guo   +5 more
doaj   +1 more source