Results 51 to 60 of about 752,560 (269)

Antibody–Drug Conjugates for Cancer Therapy

Biomedicines, 2016
Antibody–drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Adam C. Parslow, Sagun Parakh, Fook-Thean Lee, Hui K. Gan, Andrew M. Scott   +4 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment

Nature Communications
With the success of immunotherapy in cancer, understanding the tumor immune microenvironment (TIME) has become increasingly important; however in pediatric brain tumors this remains poorly characterized.
Adrian B. Levine, Liana Nobre, Anirban Das, Scott Milos, Vanessa Bianchi, Monique Johnson, Nicholas R. Fernandez, Lucie Stengs, Scott Ryall, Michelle Ku, Mansuba Rana, Benjamin Laxer, Javal Sheth, Stefanie-Grace Sbergio, Ivana Fedoráková, Vijay Ramaswamy, Julie Bennett, Robert Siddaway, Uri Tabori, Cynthia Hawkins   +19 more
doaj   +1 more source

Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

Nature Communications, 2018
ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2.
Kristina Kovač, Anja Sauer, Igor Mačinković, Stephan Awe, Florian Finkernagel, Helen Hoffmeister, Andreas Fuchs, Rolf Müller, Christina Rathke, Gernot Längst, Alexander Brehm   +10 more
doaj   +1 more source

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

Nature Communications, 2020
Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.
S. Di Blasio, G. F. van Wigcheren, A. Becker, A. van Duffelen, M. Gorris, K. Verrijp, I. Stefanini, G. J. Bakker, M. Bloemendal, A. Halilovic, A. Vasaturo, G. Bakdash, S. V. Hato, J. H. W. de Wilt, J. Schalkwijk, I. J. M. de Vries, J. C. Textor, E. H. van den Bogaard, M. Tazzari, C. G. Figdor   +19 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Coprevalence of modifiable gastric cancer risk factors and gastric health among Chinese high-risk groups

Scientific Reports
This study aims to characterise the distribution and co-prevalence patterns of 11 modifiable gastric cancer (GC) risk factors and to examine their association with gastric health. The research utilised baseline data from the upper gastrointestinal cancer
Xiang Feng, Jinhua Zhu, Chun Dai, Zhaolai Hua, Jiashan Zhu   +4 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

The Tumour Bank at the Children’s Hospital at Westmead: An Australian Paediatric Cancer Biorepository

Open Journal of Bioresources, 2018
The Tumor Bank at The Children’s Hospital at Westmead was established in 1998 with the purpose of facilitating research into childhood malignancy through the active provision of well annotated, ethically collected tissue samples and providing a pathway ...
Li Zhou, Aysen Yuksel, Oksana Markovich, Natalie Gabrael, Daniel Catchpoole   +4 more
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source