Results 81 to 90 of about 1,360,599 (360)

3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination

Scientific Reports, 2021
Studying medulloblastoma, the most common malignant paediatric brain tumour, requires simple yet realistic in vitro models. In this study, we optimised a robust, reliable, three-dimensional (3D) culture method for medulloblastoma able to recapitulate the
Sophie J. Roper, Franziska Linke, Paul J. Scotting, Beth Coyle   +3 more
doaj   +1 more source

Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host [PDF]

, 2017
Purpose: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival.
Clark, Jennifer, Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James H., Quinn, Jean A., Roxburgh, Campbell, Van Wyk, Hester C.   +7 more
core   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Systematic comparison of quantity and quality of RNA recovered with commercial FFPE tissue extraction kits

Journal of Translational Medicine
Background FFPE tissue samples are commonly used in biomedical research and are a valuable source for next-generation sequencing in oncology, however, extracting RNA from these samples can be difficult the quantity and quality achieved can impact the ...
Sukoluhle Dube, Sharefa Al-Mannai, Li Liu, Sara Tomei, Satanay Hubrack, Shimaa Sherif, Ayesha Jabeen, Eiman I. Ahmed, Apryl Sanchez, William Mifsud, Davide Bedognetti, Wouter Hendrickx, Christophe M. Raynaud   +12 more
doaj   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

Antibody–Drug Conjugates for Cancer Therapy

Biomedicines, 2016
Antibody–drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Adam C. Parslow, Sagun Parakh, Fook-Thean Lee, Hui K. Gan, Andrew M. Scott   +4 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

A Machine Learning approach for classification of ovarian tumours [PDF]

, 2022
H. Heartlin Maria, A. Maria Jossy, S. Malarvizhi   +2 more
openalex   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain, AJ Boivin, B Hendrich, BC Richardson, C Anacleto, C Grunau, CA Eads, E Bair, E Papouli, EE Cameron, F Lyko, G Egger, G Gifford, G Strathdee, G Strathdee, HG Chang, J Hall, J M Teodoridis, J Tra, JA Plumb, JF Costello, JG Herman, JM Teodoridis, JM Teodoridis, JP Issa, K Yamashita, L Zhang, LA Loeb, M Daskalakis, M Esteller, M Esteller, M Esteller, M Lachner, M Toyota, ME Valk-Lingbeek, MF Paz, MF Paz, MM Gottesman, MS Soengas, NP Bhattacharyya, PJ Johnson, PM Warnecke, R Agarwal, R Brown, R Brown, R M Glasspool, S Fulda, SH Wei, SH Wei, SL Gerson, SM Taylor, SW Lowe, T Taniguchi, T Ushijima, TH Huang, W Fischle, Y Pommier, Z Xiong   +57 more
core   +2 more sources

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source