Results 21 to 30 of about 128,770 (269)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study on Lining Cracking Damage Mechanism and Control Optimization of Mudstone Railway Tunnel

Advances in Civil Engineering
Ensuring the long-term stability of tunnels in soft rock masses, particularly water-sensitive mudstone, poses a significant challenge in railway engineering.
Haoyang Zhu, Yanbin Luo, Wurong Jia, Jiangsheng Xie, Pingan Wang, Qingsong Wang, Shangkun Guo, Xianlin He, Malongzhi Wan   +8 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Synergistic Evolution Characteristics and Driving Factors of High-Quality Economic Development and Green Space Ecological Benefits at Multiple Spatial Scales: Evidence from Shanxi Province, China

Land
Balancing economic growth with the decline in ecosystem service functions presents a critical global challenge in the 21st century. In response to the United Nations Development Programme’s emphasis on localizing Sustainable Development Goals, China has ...
Zhen Liu, Xiaodan Li, Haoyu Tao, Qi Yang, Zhiping Liu, Jing Li   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Coal and Gas Outburst Behavior in Gas-Bearing Tunnels Revealed Through an Interpretable ISSA-DNN Learning Framework

Geofluids
Coal and gas outbursts represent one of the most severe safety hazards during the construction of gas-bearing tunnels. Accurate risk prediction remains difficult because of complex geological conditions, limited sample sizes, and the inherent ...
Fangyin Wu, Wenbo Yang, Zhiyu Chen, Jian Yan, Wenyu Xu, Lina Wen   +5 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

Experimental study on joint sensing and early warning method of landslide disaster based on NPR-OFST

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In order to explore more effective methods of landslide disaster monitoring and controlling, NPR anchor cable and optical fiber grating strain sensor are physically combined to form a slope reinforcement-monitoring integration system, with PVC pipe an ...
Zhigang Tao, Yuxiang Feng, Xiaoyu Zhang, Zhehan Yu   +3 more
doaj   +1 more source