Results 31 to 40 of about 770,468 (299)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Study on Lining Cracking Damage Mechanism and Control Optimization of Mudstone Railway Tunnel

Advances in Civil Engineering
Ensuring the long-term stability of tunnels in soft rock masses, particularly water-sensitive mudstone, poses a significant challenge in railway engineering.
Haoyang Zhu, Yanbin Luo, Wurong Jia, Jiangsheng Xie, Pingan Wang, Qingsong Wang, Shangkun Guo, Xianlin He, Malongzhi Wan   +8 more
doaj   +1 more source

Tunneling times with covariant measurements

, 2009
We consider the time delay of massive, non-relativistic, one-dimensional particles due to a tunneling potential. In this setting the well-known Hartman effect asserts that often the sub-ensemble of particles going through the tunnel seems to cross the ...
A. Enders, A. Ruschhaupt, A.M. Steinberg, A.S. Holevo, A.S. Holevo, C. Carmeli, E.B. Davies, E.C. Titchmarsh, G. Ludwig, G. Nimtz, H. Dym, J. Kijowski, J. Kiukas, J.D. Dollard, M. Büttiker, M. Christ, M. Christ, M. Reed, M. Reed, N.I. Akhiezer, P. Busch, P. Deift, P. Deift, R. F. Werner, R. Werner, R.Y. Chiao, S.T. Ali, T.E. Hartman, W. Pauli   +28 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comprehensive Study of the Aerodynamic Influence of Ground and Wheel States on the Notchback DrivAer

Energies, 2022
This paper conducts an analysis of the aerodynamic influence of different ground and wheel states on the Notchback DrivAer by numerical simulation. The effects of the moving ground and rotating wheels are investigated individually and comprehensively ...
Xiaoyan Yu, Qing Jia, Zhigang Yang
doaj   +1 more source

Aeroelastic instability stoppers for wind tunnel models [PDF]

, 1981
A mechanism for diverting the flow in a wind tunnel from the wing of a tested model is described. The wing is mounted on the wall of a tunnel. A diverter plate is pivotally mounted on the tunnel wall ahead of the model. An actuator fixed to the tunnel is
Doggett, R. V., Jr., Ricketts, R. H.
core   +2 more sources

Tunneling magnetothermopower in magnetic tunnel junctions [PDF]

Physical Review B, 2014
Thermally induced spin-dependent transport across magnetic tunnel junctions (MTJs) is theoretically investigated. We analyze the thermal analog of Slonczewski's model (as well as its limiting case—Julliere's model) of tunneling magnetoresistance and obtain analytical expressions for the junction thermopower and the tunneling magnetothermopower (TMT ...
Lopez-Monis, Carlos, Matos-Abiague, Alex, Fabian, Jaroslav   +2 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Coal and Gas Outburst Behavior in Gas-Bearing Tunnels Revealed Through an Interpretable ISSA-DNN Learning Framework

Geofluids
Coal and gas outbursts represent one of the most severe safety hazards during the construction of gas-bearing tunnels. Accurate risk prediction remains difficult because of complex geological conditions, limited sample sizes, and the inherent ...
Fangyin Wu, Wenbo Yang, Zhiyu Chen, Jian Yan, Wenyu Xu, Lina Wen   +5 more
doaj   +1 more source