Results 151 to 160 of about 14,530 (266)

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Intrinsic annealing in a hybrid memristor-magnetic tunnel junction Ising machine. [PDF]

Nat Commun
Iftakher MA, Levices H, Harabi KE, Renaudineau A, Faye MC, Bouchard C, Disdier F, Viala B, Vianello E, Talatchian P, Garello K, Querlioz D, Hutin L.   +12 more
europepmc   +1 more source

Cycling Waveform Dependent Wake-Up and ON/OFF Ratio in Al₂O₃/Hf_0.5Zr_0.5O₂ Ferroelectric Tunnel Junction Devices. [PDF]

ACS Appl Electron Mater, 2023
Shajil Nair K, Holzer M, Dubourdieu C, Deshpande V.   +3 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

A parallel magnetic tunnel junction-based probabilistic Ising processor for efficient quadratic optimization. [PDF]

Nat Commun
Yang S, Bao Y, Humianto E, Prabhakar A, Yang H.   +4 more
europepmc   +1 more source

Molecular coupling competing with defects within insulator of the magnetic tunnel junction-based molecular spintronics devices. [PDF]

Sci Rep, 2021
Tyagi P, Brown H, Grizzle A, D'Angelo C, Dahal BR.   +4 more
europepmc   +1 more source

A Crack‐Based One‐Dimensional Microspheres Array Enables Thermal–Mechanical Decoupled Dual‐Functional Sensing

Advanced Science, EarlyView.
Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu, Hongyi Tu, Zehao Wang, Tianyu Zhu, Chao Wang, Min Chen, Lan Shi, Limin Wu   +7 more
wiley   +1 more source

Giant Spin-flop magnetoresistance in a collinear antiferromagnetic tunnel junction. [PDF]

Nat Commun
Xu S, Zhang Z, Mahfouzi F, Huang Y, Cheng H, Dai B, Kim J, Zhu D, Cai W, Shi K, Guo Z, Cao K, Hong B, Liu Y, Yang J, Zhang K, Cao J, Zhu F, Tai L, Wang Y, Eimer S, Fert A, Wang KL, Kioussis N, Zhang Y, Zhao W.   +25 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Magnetic tunnel junction made of abundant materials for memory and dynamic applications. [PDF]

Sci Rep
Cierpiał M, Maślanka D, Gubała K, Mojsiejuk J, Grochot K, Wrona J, Langer J, Nan T, Skowroński W.   +8 more
europepmc   +1 more source