Results 61 to 70 of about 37,712 (344)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Interpreting Soft Sediment Deformation and Mass Transport Deposits as Seismites in the Dead Sea Depocenter [PDF]

, 2018
Peer reviewedPublisher ...
Agnon, Al-Zoubi, Alsop, Alsop, Alsop, Alsop, Alsop, Alsop, Ambraseys, Amiran, Avşar, Baas, Babonneau, Bartov, Bartov, Becker, Begin, Begin, Ben-Menahem, Berryman, Brink, Calvo, Carton, Cukur, El-Isa, Enzel, Field, Freund, Garfunkel, Garfunkel, Garfunkel, Garfunkel, Gladkov, Greb, Haase-Schramm, Heifetz, Hsü, Jiang, Kagan, Kagan, Kagan, Katz, Ken-Tor, Kitagawa, Klinger, Li, Liu-Zeng, Lu, Manspeizer, Marco, Marco, Marco, Marco, McHugh, McHugh, McHugh, McHugh, McHugh, McKEE, Migowski, Moernaut, Moernaut, Molina, Monecke, Monecke, Moretti, Moretti, Moretti, Neev, Nehorai, Neugebauer, Owen, Papatheodorou, Pedersen, Piper, Polonia, Praet, Prasad, Sakaguchi, Scharer, Schnellmann, Schnellmann, Schramm, Seilacher, Shapira, Shilts, Sims, Sims, Sirkes, Smith, Sneh, Stein, Stein, Stein, Stiller, Strasser, Strasser, Strasser, Torfstein, Torfstein, Van Daele, Van Daele, Van Loon, Waldmann, Wetzler, Wilhelm   +105 more
core   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

From flood to turbidity current: combined models to simulate continent to ocean sediment transport in the Var system, France

Sedimentologika
Turbidity currents are a form of gravity-driven flow that occurs in subaqueous environments. These currents contain a low volumetric percentage of particles but are very important in transporting them from coastal to deep-marine environments. In the Var
Arthur Remaud, John J. Armitage, Vanessa Teles, Sébastien Rohais, Thierry Mulder   +4 more
doaj   +1 more source

Effect of the Grijalva-Usumacinta system on the circulation adjacent to the eastern shelf of Yucatan

Frontiers in Marine Science, 2023
Turbidity is a good indicator to determine the quality of the water; it is a measure of the number of particles in suspension in the water. Using ocean color data, we analyzed the seasonal variability of turbidity in front of the Campeche Bank and part ...
Luis Soto-Mardones, Alejando Parés-Sierra, K. Elsy Ticse de la Torre, Ana Laura Flores-Morales   +3 more
doaj   +1 more source

Reconnaissance surveying of Bechevin Bay, AK using satellite-derived bathymetry [PDF]

, 2015
Recently, a remote sensing study has been conducted over Bechevin Bay Channel, Alaska as part of a collaboration project between NOAA and the U.S. Coast Guard (USCG).
Gonsalves, Michael, Keown, Patrick, Nyberg, John, Pe\u27eri, Shachak, Snyder, Leland P.   +4 more
core   +1 more source

Mapping the Canyon [PDF]

In this activity, students will learn about the bathymetry of Hudson Canyon, a submarine canyon on the Atlantic coast of North America. As they study Hudson Canyon, they will compare and contrast topographic maps and bathymetric maps, investigate the ...

core   +1 more source

Comment on Reply to Comment of Finger et al. (2013) on: 'Evidence for an Early-Middle Miocene age of the Navidad Formation (central Chile): Paleontological, paleoclimatic and tectonic implications' of Gutiérrez et al. (2013, Andean Geology 40 (1): 66-78) [PDF]

, 2014
Indexación: Web of Science; ScieloIn their answer to our Comment (Finger et al., 2013), Le Roux et al. (2013) misunderstand several of our remarks and present what we view as f lawed arguments, principally their case for a shallow-marine environment for ...
Contardo, Ximena, Encinas, Alfonso, Finger, Kenneth L., Nielsen, Sven N   +3 more
core   +1 more source

β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, EarlyView.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source