Results 151 to 160 of about 1,541,181 (239)

Levetiracetam inhibits the Na+ HCO3− transporter Ncbe/NBCn2 (Slc4a10) in the choroid plexus of mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim The Na+‐dependent Cl−/HCO3− exchanger Ncbe/NBCn2 (Slc4a10) constitutes a major basolateral HCO3− uptake pathway in the choroid plexus and contributes to cerebrospinal fluid secretion and pH regulation. This study examined whether levetiracetam inhibits Ncbe/NBCn2‐mediated transport and alters cerebrospinal fluid acid–base balance ...
Laura Øllegaard Johnsen, Lasse Messell Desdorf, Nicoline Stærke Jensen, Jeppe Praetorius, Helle Hasager Damkier   +4 more
wiley   +1 more source

Input structure-driven instability and convergence in large language model clinical reasoning: a formative study using pediatric residency-level MCQs. [PDF]

Sci Rep
James V, Caronia C, Savargaonkar R.
europepmc   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

DR-CoT: dynamic recursive chain of thought with meta reasoning for parameter efficient models. [PDF]

Sci Rep
Sinha A, Umakanthan OC, Gajendran S.
europepmc   +1 more source

AlquistCoder: A Synthetic Data Approach to Training Compact Secure Coding Assistants and Building Security Benchmarks

Computational Intelligence, Volume 42, Issue 4, August 2026.
ABSTRACT Large language models are increasingly used as programming assistants, but their security behavior remains uneven: they may generate code with vulnerable patterns, and they may provide actionable help for malicious requests. This paper introduces AlquistCoder, a compact 3.8B‐parameter coding assistant designed to address both risks through ...
Ondřej Kobza, Adam Černý, Ivan Dostál, Jan Šedivý, Maria Rigaki, Muris Sladić, Sebastian Garcia   +6 more
wiley   +1 more source

Evaluating large language model performance and reliability in scoring picture description tasks for neuropsychological assessment. [PDF]

PLOS Digit Health
Kleiman MJ.
europepmc   +1 more source

Small Language Models: A Systematic Review of Computational Trade‐Offs, Privacy Advantages and Deployment in Intelligent Systems

Expert Systems, Volume 43, Issue 8, August 2026.
ABSTRACT This systematic review synthesizes evidence from 68 studies, including peer‐reviewed journal articles, indexed conference/workshop proceedings and five remaining arXiv preprints published between 2022 and 2025, on small language models (SLMs) as computationally efficient alternatives to large language models (LLMs).
Sena Dikici, Turgay Tugay Bilgin
wiley   +1 more source

Large Language Models in Randomized Controlled Trials Design: Observational Study. [PDF]

J Med Internet Res
Jin L, Ong JCL, Elangovan K, Ke Y, Pyle A, Ting DSW, Liu N.   +6 more
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Evaluating Large Language Models for Preoperative Patient Education in Superior Capsular Reconstruction: Comparative Study of Claude, GPT, and Gemini. [PDF]

JMIR Perioper Med
Liu Y, Li H, Ouyang J, Xue Z, Wang M, He H, Song B, Zheng X, Gan W.   +8 more
europepmc   +1 more source