Results 41 to 50 of about 5,785 (266)

Transitional–turbulent spots and turbulent–turbulent spots in boundary layers [PDF]

open access: yesProceedings of the National Academy of Sciences, 2017
Significance Uncovering the constitutive coherent structure in the inner layer of the canonical turbulent boundary layer has remained a central fluid mechanics theme, because it tests our intellectual ability to understand even the simplest external flow.
Xiaohua, Wu   +5 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Particle-Laden Two-Phase Boundary Layer: A Review

open access: yesAerospace
The presence of solid particles (or droplets) in a flow leads to a significant increase in heat fluxes, the occurrence of chemical reactions, and erosive surface wear of various aircraft moving in the dusty (or rainy) atmosphere of Earth or Mars.
Aleksey Yu. Varaksin, Sergei V. Ryzhkov
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Experimental investigation on evolution characteristics of high- and low-speed streaks in supersonic turbulent boundary layer

open access: yesAIP Advances, 2022
High-speed and low-speed streak structures in the near wall region of a turbulent boundary layer with a Mach number of 3 are experimentally examined by employing the spatiotemporally resolved nanoparticle plane laser scattering technique.
Junhao Han, Lin He, Zhengbang Wu
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Direct Assessment of Langmuir Turbulence Parameterizations in Idealized Coastal Merging Boundary Layers

open access: yesJournal of Advances in Modeling Earth Systems
Langmuir turbulence affects turbulent mixing in the ocean boundary layers and its effects require parameterizations in ocean circulation models. Most existing Langmuir turbulence parameterizations focus on the surface boundary layer in open oceans.
Zheng Wei, Qing Li, Bicheng Chen
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Soft turbulence in the atmospheric boundary layer

open access: yesAIP Conference Proceedings, 1993
In this work we compare the spectral properties of the daily medium temperature fluctuations with the experimental results of the Chicago Group, in which the local temperature fluctuations were measured in a helium cell. The results suggest that the dynamics of the daily temperature fluctuations is determined by the oft turbulent state of the ...
Jánosi, Imre M., Vattay, Gábor
openaire   +2 more sources

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