Results 41 to 50 of about 5,771 (267)

Transitional–turbulent spots and turbulent–turbulent spots in boundary layers [PDF]

Proceedings of the National Academy of Sciences, 2017
SignificanceUncovering the constitutive coherent structure in the inner layer of the canonical turbulent boundary layer has remained a central fluid mechanics theme, because it tests our intellectual ability to understand even the simplest external flow.
Xiaohua, Wu, Parviz, Moin, James M, Wallace, Jinhie, Skarda, Adrián, Lozano-Durán, Jean-Pierre, Hickey   +5 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Particle-Laden Two-Phase Boundary Layer: A Review

Aerospace
The presence of solid particles (or droplets) in a flow leads to a significant increase in heat fluxes, the occurrence of chemical reactions, and erosive surface wear of various aircraft moving in the dusty (or rainy) atmosphere of Earth or Mars.
Aleksey Yu. Varaksin, Sergei V. Ryzhkov
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Experimental investigation on evolution characteristics of high- and low-speed streaks in supersonic turbulent boundary layer

AIP Advances, 2022
High-speed and low-speed streak structures in the near wall region of a turbulent boundary layer with a Mach number of 3 are experimentally examined by employing the spatiotemporally resolved nanoparticle plane laser scattering technique.
Junhao Han, Lin He, Zhengbang Wu
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A Direct Assessment of Langmuir Turbulence Parameterizations in Idealized Coastal Merging Boundary Layers

Journal of Advances in Modeling Earth Systems
Langmuir turbulence affects turbulent mixing in the ocean boundary layers and its effects require parameterizations in ocean circulation models. Most existing Langmuir turbulence parameterizations focus on the surface boundary layer in open oceans.
Zheng Wei, Qing Li, Bicheng Chen
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Soft turbulence in the atmospheric boundary layer

AIP Conference Proceedings, 1993
In this work we compare the spectral properties of the daily medium temperature fluctuations with the experimental results of the Chicago Group, in which the local temperature fluctuations were measured in a helium cell. The results suggest that the dynamics of the daily temperature fluctuations is determined by the oft turbulent state of the ...
Jánosi, Imre M., Vattay, Gábor
openaire   +2 more sources