Results 51 to 60 of about 455,438 (280)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Scale-to-scale information flow amplifies turbulent fluctuations
Physical Review ResearchIn three-dimensional turbulence, information of turbulent fluctuations at large scales is propagated to small scales. Here, we investigate the relation between the information flow and turbulent fluctuations described by a shell model. We first establish
Tomohiro Tanogami, Ryo Araki
doaj +1 more source
Известия высших учебных заведений: Проблемы энергетики, 2019 Models and methods for studying turbulence based on the concept of turbulent "vortex backfill" are presented. The essence of this concept is that the turbulent flow is considered as laminar, flowing through a "vortex backfill ", which creates internal ...
L. E. Melamed, G. A. Filippov
doaj +1 more source
Test problem of flow modelling in the Rotor 37 compressor stage
Авіаційно-космічна техніка та технологія, 2023 The subject of the study is the dependence of the degree of pressure increase on the airflow in the impeller of the axial compressor degree. The object of study is the Rotor 37 axial compressor.
Andrii Duliepov +4 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Large-scale mean patterns in turbulent convection
, 2015 Large-scale patterns, which are well-known from the spiral defect chaos regime of thermal convection at Rayleigh numbers $Ra < 10^4$, continue to exist in three-dimensional numerical simulations of turbulent Rayleigh-B\'{e}nard convection in extended ...
Emran, Mohammad S., Schumacher, Jörg
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Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Turbulent Micropolar Open-Channel Flow
FluidsThe present paper focuses on the investigation of the turbulent characteristics of an open-channel flow by employing the micropolar model. The underlying model has already been proven to correctly describe the secondary phase of turbulent wall-bounded ...
George Sofiadis +3 more
doaj +1 more source