Results 51 to 60 of about 122,095 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Flow around a cube in a turbulent boundary layer: LES and experiment [PDF]

open access: yes, 2009
We present a numerical simulation of flow around a surface mounted cube placed in a turbulent boundary layer which, although representing a typical wind environment, has been specifically tailored to match a series of wind tunnel observations.
Thomas, T.G.   +2 more
core   +1 more source

Turbulent kinetic energy flux and budget in a water-worked gravel bed

open access: yesE3S Web of Conferences, 2018
Turbulent flow over a water-worked gravel bed (WGB) was investigated using the double-averaging methodology (DAM). The flow measurements were carried out by the particle image velocimetry (PIV) technique.
Padhi Ellora   +4 more
doaj   +1 more source

Large-eddy simulation of wall-bounded turbulent flow with high-order discrete unified gas-kinetic scheme

open access: yesAdvances in Aerodynamics, 2020
In this paper, we introduce the discrete Maxwellian equilibrium distribution function for incompressible flow and force term into the two-stage third-order Discrete Unified Gas-Kinetic Scheme (DUGKS) for simulating low-speed turbulent flows.
Rui Zhang   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Acceleration in turbulent channel flow

open access: yes, 2010
We use Direct Numerical Simulations of turbulent channel flow to study the acceleration A corresponding to the full fluid velocity u and the acceleration a corresponding to the fluctuating velocity u? ? u?hui where hui is the mean flow.
S. W. Coleman   +7 more
core   +1 more source

Turbulent flow in pulsed extraction columns with internals of discs and rings:Turbulent kinetic energy and its dissipation rate during the pulsation [PDF]

open access: yes, 2009
Turbulent energy parameters of single-phase pulsed flow in an extraction column with internals of immobile discs and rings (doughnuts) are studied. Simulation results are obtained by resolution of Reynolds equations coupled with k–ɛ model of turbulence ...
Angelov, George, Gourdon, Christophe
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Modelling of turbulent swirling flows [PDF]

open access: yes, 2004
This thesis investigates the predictability of non-reacting and reacting anistropic turbulent, swirling flows using popular turbulence models with a robust numrical procedure. The performance of these turbulence models is assessed and compared against
Jones, Lee Nicholas
core  

Two-phase flow patterns in turbulent flow through a dose diffusion pipe

open access: yes, 2005
A numerical investigation is carried out for turbulent particle-laden flow through a dose diffusion pipe for a model reactor system. A Lagrangian Stochastic Monte-Carlo particle-tracking approach and the averaged Reynolds equations with a k-e turbulence ...
Tang, H   +5 more
core   +1 more source

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