Results 31 to 40 of about 18,315 (267)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structure of Turbulent Channel Flow under Spanwise System Rotation

Journal of Fluid Science and Technology, 2007
Direct numerical simulation of turbulent channel flow under spanwise system rotation is performed. When system rotation is imposed on turbulent Poiseuille flow, the Reynolds number decreases in one side of a channel, while it increases in the other side.
Oaki IIDA, Kenji MIYAMOTO, Yasutaka NAGANO   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Vegetated Channel Flows: Turbulence Anisotropy at Flow–Rigid Canopy Interface

Geosciences, 2018
This laboratory study aimed at investigating the mean and turbulent characteristics of a densely vegetated flow by testing four different submergence ratios.
Gerardo Caroppi, Paola Gualtieri, Nicola Fontana, Maurizio Giugni   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Numerical Study of Entropy Generation due to Coupled Laminar and Turbulent Mixed Convection and Thermal Radiation in an Enclosure Filled with a Semitransparent Medium

The Scientific World Journal, 2014
The effect of radiation on laminar and turbulent mixed convection heat transfer of a semitransparent medium in a square enclosure was studied numerically using the Finite Volume Method.
M. Goodarzi, M. R. Safaei, Hakan F. Oztop, A. Karimipour, E. Sadeghinezhad, M. Dahari, S. N. Kazi, N. Jomhari   +7 more
doaj   +1 more source

Advances in research on turbulence structure in vegetated open channel flows

Shui kexue jinzhan, 2014
Aquatic plants in natural rivers have important effects on turbulence structure. In the presence of vegetation,river flows become more intensely mixed and their turbulent structures are more complicated.
YAN Jing, DAI Kun, TANG Hongwu, CHENG Niansheng, CHEN Yang   +4 more
doaj   +1 more source

Lattice Boltzmann Method Modeling of the Evolution of Coherent Vortices and Periodic Flow in a Continuous Casting Mold

Metals, 2022
Transient phenomena and vortex structures throughout the mold are simulated using a lattice Boltzmann method (LBM) coupled with large eddy simulation (LES) using a free surface model under steady operating conditions.
Peng Zhao, Rongxun Piao
doaj   +1 more source