Results 71 to 80 of about 21,181 (318)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Numerical Heat Transfer Study of Liquid Metal in Triangular Rod Bundle Based on k-ε-kθ-εθ Model
Yuanzineng kexue jishu, 2022 Compared with the constant turbulent Prandtl number (Prt) model, a four-equation model considers the difference between the velocity and temperature boundary layer of liquid metals by introducing the turbulence time-scale, which is expected to improve ...
SU Xingkang;GU Long;LI Xianwen;ZHANG Lu;SHENG Xin
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2015 The work reported in this paper is a numerical study of airflow and heat transfer for low turbulence buoyancy-driven flow in a rectangular cavity partially filled with solid objects.
Hasan, Reaz, Iyi, Draco
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Heat transfer in turbulized gradient flows
Journal of Physics: Conference Series, 2020 Abstract Convective heat transfer in a plane channel with superimposed pressure gradient (converging and diverging channel) has been studied experimentally. The air flow was turbulized by different arrangements at the channel inlet. Distributions of heat transfer coefficients within the gradient part of the channel have been obtained in ...
I A Davletshin +2 more
openaire +1 more source
On the use of the boundary layer integral equations for the prediction of skin friction and heat transfer [PDF]
, 1986 The usefulness of the energy equation integrated over the thickness of the boundary layer, in predicing heat transfer rates to smooth body surfaces in investigated.
Hellon, C. S.
core
Direct numerical simulation of turbulent scalar transport across a flat surface [PDF]
, 2014 To elucidate the physical mechanisms that play a role in the interfacial transfer of atmospheric gases into water, a series of direct numerical simulations of mass transfer across the air-water interface driven by isotropic turbulence diffusing from ...
Herlina, H +3 more
core +1 more source