Results 101 to 110 of about 1,908,978 (257)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Cross Diffusion Induced Turing Patterns in a Tritrophic Food Chain Model with Crowley-Martin Functional Response

Mathematics, 2019
Diffusion has long been known to induce pattern formation in predator prey systems. For certain prey-predator interaction systems, self diffusion conditions ceases to induce patterns, i.e., a non-constant positive solution does not exist, as seen from ...
Nitu Kumari, Nishith Mohan
doaj   +1 more source

Coverage‐based rarefaction fails to quantify relative species richness

Oikos, EarlyView.
Coverage‐based rarefaction (CBR) is a high‐profile tool for assessing biodiversity that provides relative species richness estimates by leveraging the Good‐Turing index u to interpolate. In contrast to alternatives such as the Shannon and Simpson indices, CBR's main appeal is providing values in units of species. CBR is tested against a series of other
John Alroy
wiley   +1 more source

High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

eLife, 2016
The Turing reaction-diffusion model explains how identical cells can self-organize to form spatial patterns. It has been suggested that extracellular signaling molecules with different diffusion coefficients underlie this model, but the contribution of ...
Luciano Marcon, Xavier Diego, James Sharpe, Patrick Müller   +3 more
doaj   +1 more source

The Turing Online Training Grant 2020 awarded to The Turing Way and Open Life Science teams

, 2020
Successful proposal to the Turing Online Training Grant 2020 - Awarded to The Turing Way and Open Life Science Cite this as: Sharan, M., Whitaker, K., Yehudi, Y., The Turing Online Training Gran 2020 awarded to The Turing Way and Open Life Science ...
Yehudi, Yo, Sharan, Malvika, Whitaker, Kirstie   +2 more
core   +1 more source

The first RNAi‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Pest Management Science, EarlyView.
The approval of the RNA interference‐based biopesticide Ledprona (Calantha™) in the USA marks a milestone for RNA‐based crop protection. We discuss the regulatory implications for the European Union, highlighting opportunities, challenges, and the need for adapted risk assessment frameworks for RNA‐based plant protection products.
Aline Koch, Gabi Krczal
wiley   +1 more source

Numerical framework and stability analysis of the Gray-Scott model

Open Computer Science
Turing models of pattern formation provide insight into an intriguing question in developmental biology, like how nature exhibits various structures, shapes, and organized patterns. These natural patterns include the pattern and texture on a desert dune,
Ali Ramzan, Ahmed Attique
doaj   +1 more source

Emergence of Diverse Epidermal Patterns via the Integration of the Turing Pattern Model with the Majority Voting Model

Biophysica
Animal skin patterns are increasingly explained using the Turing pattern model proposed by Alan Turing. The Turing model, a self-organizing model, can produce spotted or striped patterns.
Takeshi Ishida
doaj   +1 more source

Environmental Stressors Influence Spatial Complexity in a Fluvial Macrophyte meadow

Remote Sensing in Ecology and Conservation, EarlyView.
This research investigates the nonlinear relationships between environmental stressors and the fine‐scale spatial complexity of a fluvial macrophytes meadow. The use of multivariate spatial analysis allowed us to identify two major environmental gradients (nutrients and light) and two major complexity gradients (related to abundance and fragmentation).
Arthur de Grandpré, Christophe Kinnard, Andrea Bertolo   +2 more
wiley   +1 more source

Bifurcation analysis of a predator-prey system with self- and cross-diffusion and constant harvesting rate

Electronic Journal of Qualitative Theory of Differential Equations, 2014
In this paper, we focus on a ratio dependent predator-prey system with self- and cross-diffusion and constant harvesting rate. By making use of a brief stability and bifurcation analysis, we derive the symbolic conditions for Hopf, Turing and wave ...
Hunki Baek
doaj   +1 more source