Results 51 to 60 of about 4,220,519 (287)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Turn-Taking Between Provisioning Parents: Partitioning Alternation
Frontiers in Ecology and Evolution, 2019 How parents negotiate over parental care is a central issue in evolutionary biology because it affects the evolutionary outcome of sexual conflict.
Davide Baldan +3 more
doaj +1 more source
Fluency in dialogue: Turn‐taking behavior shapes perceived fluency in native and nonnative speech
, 2020 Fluency is an important part of research on second language learning, but most research on language proficiency typically has not included oral fluency as part of interaction, even though natural communication usually occurs in conversations. The present
Bosker, H., De Jong, N., Van Os, M.
core +1 more source
Cohomological invariants of a variation of flat connection [PDF]
, 2015 In this paper, we apply the theory of Chern-Cheeger-Simons to construct canonical invariants associated to a $r$-simplex whose points parametrize flat connections on a smooth manifold $X$.
Iyer, Jaya N. N.
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
, 2018 <strong> BOSC 2019 will be part of ISMB 2019 </strong> Every year until 2018, BOSC was part of the annual ISMB conference as a community of special interest (COSI, formerly known as a SIG, Special Interest Group). As part of our continuing quest to broaden and deepen the BOSC community, we decided to perform an experiment this year by ...
openaire +2 more sources
The use of content and timing to predict turn transitions
Frontiers in Psychology, 2015 For addressees to respond in a timely fashion, they cannot simply process the speaker’s utterance as it occurs and wait till it finishes. Instead, they predict both when the speaker will conclude and what linguistic forms they will use.
Simon eGarrod, Martin J. Pickering
doaj +1 more source