Results 71 to 80 of about 1,421,602 (199)

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

open access: yesAdvanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu   +14 more
wiley   +1 more source

Turner Contemporary: art inspiring change. social value report (15/16) [PDF]

open access: yes, 2016
This study focuses on the social value created by Turner Contemporary. The research and analysis was undertaken by the COaST research group at Canterbury Christ Church University on behalf of Turner Contemporary.
Nettley, A.   +3 more
core  

Deep Eutectic Solvent‐Enhanced PEDOT: PSS/NR Foam Piezoresistive Sensor for High‐Sensitivity Wearable Devices and Sleep Monitoring Applications

open access: yesAdvanced Materials Interfaces, EarlyView.
A high‐performance piezoresistive foam sensor is developed by integrating natural rubber, PEDOT: PSS, and a deep eutectic solvent (DES). DES effectively detaches insulating PSS from PEDOT, dramatically amplifying electrical conductivity and sensitivity.
Shun Zhang   +4 more
wiley   +1 more source

[Letters from J. L. Turner, Sr. to Minnie L. Turner - 1936 and 1937]

open access: yes, 1936
Two letters from J. L. Turner, Sr., to his daughter, Minnie L. Turner, the first from December 1936, and the second from November 1937. The first discusses a book recommendation she made to him and fur coats and rain shoes sent to her.
Turner, John Turner, Sr.
core  

A 13-year-old female with Turner syndrome and achalasia

open access: yesThe Turkish Journal of Pediatrics, 2006
The most common gastrointestinal problems associated with Turner syndrome are intestinal telangiectasia, colon carcinomas, inflammatory bowel, and liver diseases. In this paper we present for the first time a 13-year-old female with 45,X karyotype
Sevim Balci   +4 more
doaj  

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

open access: yesAdvanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang   +7 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Mosaic Variant of Turner Syndrome [PDF]

open access: yes, 2022
Turner syndrome is the most common chromosomal abnormality leading to gonadal failure and primary amenorrhea. While half of the cases have monosomy of chromosome X, the remaining exhibit mosaicism resulting in wide variation of phenotypic characteristics
Parneet Kaur   +4 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

open access: yesAdvanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang   +11 more
wiley   +1 more source

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